Abstract
Background
Because the stomach plays an important role in the development of satiety, gastric
function was examined in bulimia nervosa (BN).
Methods
Sixteen patients with BN and 16 controls swallowed an inflatable bag, which was positioned
in the proximal stomach. Minimal distending pressure (MDP), the pressure needed to
overcome intraabdominal pressure, was determined. Gastric volume was recorded after
subjects drank a liquid meal.
Results
MDP was similar in patient and control groups (7.56 ± 2.13 vs. 7.13 ± 2.06 mmHg; t = .57, df = 30, p = .58). Average postmeal gastric relaxation was significantly lower in the patient
group (29.7 ± 97.8 vs. 105.1 ± 103.3 mL; t = 2.13, df = 30, p = .042).
Conclusions
Stomach relaxation following food consumption is significantly diminished in patients
with BN. Physiologic abnormalities of stomach function in BN may contribute to the
perpetuation of disturbances in behavior in this disorder.
Keywords
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Article info
Publication history
Accepted:
January 24,
2003
Received in revised form:
November 28,
2002
Received:
August 7,
2002
Identification
Copyright
© 2003 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
