Abstract
Background
This study was conducted to further examine the hypothesis of abnormalities in size
of corpus callosum in subjects with bipolar disorder.
Methods
Sixteen right-handed DSM-IV bipolar I patients and 27 right-handed healthy control
subjects were studied. A 1.5-T GE Signa magnet was used, and three-dimensional gradient
echo imaging (spoiled gradient recall acquisition) was conducted. Area measurements
of corpus callosum were obtained blindly, with a semi-automated software, by a well-trained
rater.
Results
Right-handed bipolar I patients had significantly smaller total corpus callosum, genu,
posterior body, and isthmus areas compared with right-handed healthy control subjects
(analysis of covariance with age, gender, and intracranial volume as covariates, p < .05). Partial correlation analyses, controlled for intracranial volumes, found
a significant inverse relationship between age and total callosal, genu, anterior
body, isthmus, and circularity in healthy control subjects (p < .05) but not in bipolar patients (p > .05).
Conclusions
Smaller callosal areas may lead to altered inter-hemispheric communication and be
involved in the pathophysiology and cognitive impairment found in bipolar disorder.
Keywords
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References
- Fiber composition of the human corpus callosum.Brain Res. 1992; 598: 143-153
- Anatomical MRI study of basal ganglia in bipolar disorder patients.Psychiatry Res. 2001; 106: 65-80
- Systematic variations in callosal morphology.Neuropsychology. 1994; 8: 563-571
- Cognitive impairment and cerebral structure by MRI in bipolar disorder.Biol Psychiatry. 1990; 27: 1188-1196
- A.E. Bennett Research Award. Developmental traumatology. Part II.Biol Psychiatry. 1999; 45: 1271-1284
- Shape and size of the corpus callosum in schizophrenia and schizotypal personality disorder.Schizophr Res. 2000; 42: 193-208
- Development of the human corpus callosum during childhood and adolescence.Prog Neuropsychopharmacol Biol Psychiatry. 1999; 23: 571-588
- Corpus callosum size in autism.Neurology. 2000; 55: 1033-1036
- Corpus callosum dimensions measured by magnetic resonance imaging in bipolar affective disorder and schizophrenia.Biol Psychiatry. 1989; 26: 659-668
- MRI of corpus callosum and septum pellucidum in depression.Biol Psychiatry. 1991; 29: 300-301
- Development of the corpus callosum in childhood, adolescence and early adulthood.Life Sci. 2002; 70: 1909-1922
- Abnormalities of the corpus callosum in first episode, treatment naive schizophrenia.J Neurol Neurosurg Psychiatry. 2002; 72: 757-760
- The assessment and analysis of handedness.Neuropsychologia. 1971; 9: 97-113
- Magnetic-resonance morphometry in patients with major depression.Psychiatry Res. 1998; 84: 7-15
- When does human brain development end? Evidence of corpus callosum growth up to adulthood.Ann Neurol. 1993; 34: 71-75
- The anatomy of mood disorders—Review of structural neuroimaging studies.Biol Psychiatry. 1997; 41: 86-106
- Structured Clinical Interview for DSM-IV (SCID). American Psychiatric Press, Washington, DC1994
- Persistent attentional dysfunction in remitted bipolar disorder.Bipolar Disord. 2001; 3: 58-62
- The brain connection.Science. 1985; 229: 665-668
- Hand and sex differences in the isthmus and genu of the human corpus callosum. A postmortem morphological study.Brain. 1989; 112: 799-835
- Corpus callosum size and inter-hemispheric function in schizophrenia.Schizophr Res. 1997; 23: 189-196
- Magnetic resonance and positron emission tomography imaging of the corpus callosum.J Affect Disord. 1993; 28: 15-25
Article info
Publication history
Accepted:
January 9,
2003
Received in revised form:
December 4,
2002
Received:
July 11,
2002
Identification
Copyright
© 2003 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
