Abstract
Background
A functional polymorphism within the promoter of the serotonin transporter has been
shown to influence the antidepressant response to serotonergic drug treatments and
to total sleep deprivation (TSD). The short-term relapse that follows acute response
to TSD has been successfully prevented by combining TSD with light therapy. The mechanism
of action of this combined treatment is unknown.
Methods
We tested the hypothesis that allelic variation of the serotonin transporter (5-HTT)
linked polymorphic region (5-HTTLPR) could influence the response to the combination
of light therapy and TSD. Twenty-two bipolar depressed inpatients were administered
a night of TSD combined with 30 min light therapy given during the TSD night and in
the morning after recovery sleep. 5-HTTLPR was genotyped using polymerase chain reaction
techniques. Changes in perceived mood were rated on a visual analog scale.
Results
Light therapy sustained the effect of TSD. The effect was more marked in homozygotes
for the long variant of 5-HTTLPR than in heterozygotes and homozygotes for the short
variant.
Conclusions
The influence of 5-HTTLPR on response to the combination of TSD and light therapy
is similar to that observed on response to TSD and serotonergic drug treatments.
Keywords
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Article info
Publication history
Accepted:
November 8,
2002
Received in revised form:
September 30,
2002
Received:
May 20,
2002
Identification
Copyright
© 2003 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
