Abstract
Background
An enlarged cavum septum pellucidum (CSP) is a putative marker of disturbed brain
development, and it has been associated with a variety of neuropsychiatric disorders.
The goal of this study was to characterize systematically the CSP and the related
cavum vergae in individuals with Tourette syndrome (TS).
Methods
The overall size and anteroposterior length of the CSP in 161 children (97 with TS
and 64 normal pediatric control subjects) and 107 adults (43 with TS and 64 normal
adult control subjects) were rated on high-resolution magnetic resonance images in
the coronal view. The associations of CSP size with diagnosis and symptom severity
scores were assessed using ordinal logistic regression.
Results
CSP size in TS children was significantly smaller than in normal control subjects,
and it was inversely associated with attention-deficit/hyperactivity disorder symptom
severity in the TS subjects. CSP size was not significantly associated with the comorbid
diagnoses of OCD or ADHD. These results were replicated in the independent sample
of adults with TS and their same-age control subjects. The presence of a cavum vergae
was not significantly associated with a diagnosis of TS.
Conclusions
These findings suggest that the pathophysiology of TS may involve abnormalities in
the early development of the CSP or in the neighboring corpus callosum, septal nuclei,
or limbic system.
Keywords
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Article info
Publication history
Accepted:
October 16,
2002
Received in revised form:
October 9,
2002
Received:
June 25,
2002
Identification
Copyright
© 2003 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
