Abstract
Background:
Dysfunctions in brain regions known to be involved in affect and mood states are thought
to be implicated in depression and may have a role in determining the type and symptoms
of this illness.
Methods:
Functional magnetic resonance imaging was used to elucidate neural correlates of cognitive
generation of affect, using a previously published paradigm of evoking affect with
picture-caption pairs, in patients with unipolar, treatment-resistant depression.
Results:
Compared with control participants, patients showed relatively decreased response
in the anterior cingulate (rostral; right) with both negative and positive picture-caption
pairs and in the medial frontal gyrus and hippocampus (all left) with positive picture-caption
pairs. They demonstrated increased response in the inferior (right) and middle temporal
gyri (left) with negative picture-caption pairs, and in the parahippocampal gyrus
(right), inferior frontal gyrus (left), subgenual cingulate (right), striatum (right),
and brain stem (left) with positive picture-caption pairs.
Conclusions:
Reduced medial/middle prefrontal and hippocampal activity may account for positive
affect disturbances and temporal lobe hyperactivity for negative affect disturbances
in treatment-resistant depression. The results also corroborate previous observations
from resting positron emission tomography studies and further elucidate the association
between hypoactive rostral cingulate and nonresponsiveness to treatment in depression.
Keywords
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Article info
Publication history
Accepted:
October 1,
2002
Received in revised form:
September 23,
2002
Received:
April 4,
2002
Identification
Copyright
© 2003 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
