Abstract
Background
The GRIN1 gene plays a fundamental role in many brain functions, and its involvement in the
pathogenesis of the schizophrenia has been widely investigated. Non-synonymous polymorphisms
have not been identified in the coding regions. To investigate the potential role
of GRIN1 in the susceptibility to schizophrenia, we analyzed the G1001C polymorphism located
in the promoter region in a case-control association study.
Methods
The G1001C polymorphism allele distribution was analyzed in a sample of 139 Italian
schizophrenic patients and 145 healthy control subjects by a polymerase chain reaction
amplification followed by digestion with a restriction endonuclease.
Results
We found that the C allele may alter a consensus sequence for the transcription factor
NF-κB and that its frequency was higher in patients than in control subjects (p = .0085). The genotype distribution also was different, with p = .034 (if C allele dominant, p = .0137, odds ratio 2.037, 95% confidence interval 1.1502-3.6076).
Conclusions
The association reported in this study suggests that the GRIN1 gene is a good candidate for the susceptibility to schizophrenia.
Keywords
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Article info
Publication history
Accepted:
September 27,
2002
Received in revised form:
September 19,
2002
Received:
June 6,
2002
Identification
Copyright
© 2003 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
