Abstract
Background
Personality traits have shown considerable heritable components. Striatal dopamine
D2 receptor density, as determined by positron-emission tomography, has been associated
with detached personality, as assessed by the Karolinska Scales of Personality. A
putative functional promoter polymorphism in the dopamine D2 receptor gene (DRD2), –141C ins/del, has been associated with dopamine D2 receptor density.
Methods
In this study healthy subjects (n = 235) who filled in at least one of several personality questionnaires (Karolinska
Scales of Personality, Swedish Universities Scales of Personality, Health-relevant
Five-factor Personality Inventory, and Temperament and Character Inventory) were analyzed
with regard to the DRD2 –141C ins/del variant.
Results
There was an association (p = .001) between the DRD2 –141C ins/del variant and Karolinska Scales of Personality Detachment scale, indicating
higher scores in subjects with the –141C del variant. There were also associations
between the DRD2 –141C ins/del variant and a number of Karolinska Scales of Personality and Swedish
Universities Scales of Personality Neuroticism-related scales, but of these only Swedish
Universities Scales of Personality Lack of Assertiveness scale (p = .001) survived correction for multiple testing.
Conclusions
These results add further support for the involvement of dopamine D2 receptor in certain personality traits. The results should be treated with caution
until replicated.
Keywords
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Article info
Publication history
Accepted:
September 3,
2002
Received in revised form:
June 26,
2002
Received:
April 10,
2002
Identification
Copyright
© 2003 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
