Abstract
Backgroud
The dihydropyrimidinase-related protein (DRP) family, also called the collapsin response
mediator protein, is implicated in the developmental process of the nervous system.
Dysfunction of DRPs may result in neurodevelopmental abnormalities, which may be a
factor in the pathogenesis of schizophrenia. The expression of one member of DRP-2
in humans has been reported to be decreased in the brains of people with schizophrenia.
In addition, the DRP-2 gene (Dihydropyrimidinaselike 2; DPYSL2) is located on chromosome
8p21, a region that has been implicated in schizophrenia in genetic linkage studies.
Methods
We investigated a genetic association between five polymorphisms of the DRP-2 gene
and schizophrenia in the Japanese population.
Results
The *2236T>C polymorphism in the 3′ untranslated region (3′UTR) exhibited significant differences
with respect to the distribution of the genotype and allele in patients compared with
control subjects. The frequency of the *2236C allele was significantly higher in control
subjects than patients with schizophrenia (p = .0097) and paranoid-type schizophrenia (p = .0083).
Conclusions
Our results suggest that the *2236C allele in the 3′UTR of the DRP-2 gene, or an unknown
mutation in linkage disequilibrium with this allele, may reduce the susceptibility
to schizophrenia, especially the paranoid subtype.
Keywords
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Article info
Publication history
Accepted:
September 4,
2002
Received in revised form:
August 22,
2002
Received:
July 3,
2002
Identification
Copyright
© 2003 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
