Abstract
Background
Individuals with obsessive–compulsive disorder (OCD) frequently have other psychiatric
disorders. This study employed latent class analysis (LCA) to explore whether there
are underlying clinical constructs that distinguish “OCD-related” subgroups.
Methods
The study included 450 subjects, case and control probands and their first-degree
relatives, and LCA was used to derive empirically based subgroups of 10 disorders:
OCD, obsessive–compulsive personality disorder (OCPD), recurrent major depressive
disorder (RMDD), separation anxiety disorder, panic disorder or agoraphobia (PD/AG),
tic disorders (TD), generalized anxiety disorder (GAD), somatoform disorders (hypochondriasis
or body dysmorphic disorder), pathologic skin picking or nail biting (PSP/NB), and
eating disorders (EDs). The derived classes were compared on several clinical variables.
Results
The best fitting model is a four-class structure: minimal disorder, predominant RMDD
and GAD, “highly comorbid,” and PD/AG and TD. The nature and number of disorders represented
suggests that the first classes are distributed ordinally on a dimension of severity,
and the fourth class is qualitatively distinct. Support for this structure is based
on the number of disorders, age at onset of OCD, neuroticism, and extraversion.
Conclusions
In this OCD enriched sample, LCA identified four classes of disorder. These classes
appear to conform to two subgroups that may prove useful in investigating the etiology
of OCD.
Keywords
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Article Info
Publication History
Accepted:
August 22,
2002
Received in revised form:
August 13,
2002
Received:
May 14,
2001
Identification
Copyright
© 2003 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
