Advertisement
Review article| Volume 52, ISSUE 10, P947-957, November 15, 2002

The development and modification of temperamental risk for anxiety disorders: prevention of a lifetime of anxiety?

  • Ronald M Rapee
    Correspondence
    Address reprint requests to R.M. Rapee, Ph.D., Department of Psychology, Macquarie University, Sydney 2109, Australia.
    Affiliations
    Department of Psychology, Macquarie University, Sydney, Australia
    Search for articles by this author

      Abstract

      This review poses the question, is it possible to prevent the development of anxiety disorders through selective interventions? The article begins with a review of the major psychosocial risk factors for anxiety disorders. Evidence is reviewed to support the role of inhibited temperament, parent anxiety, environmental support of avoidant coping, and vicarious and instructional learning of avoidance as risks for anxiety. It is argued that the central focus of these risks is an inhibited temperament and that the other risk factors are likely to be both moderated and mediated by this temperamental style. Thus, a clear option for prevention would be to modify early inhibition. Some preliminary data are presented from the Macquarie University Preschool Intervention Project, a longitudinal study of a brief parent education program for the reduction of inhibited temperament in preschool children. Although there remains considerable room for stronger effects, preliminary results show clear promise that it may be possible to modify early risk for anxiety disorders.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Andrews G.
        Comorbidity in neurotic disorders.
        in: Rapee R.M. Current Controversies in the Anxiety Disorders. Guilford Press, New York1996: 3-20
        • Andrews G.
        • Hall W.
        • Teesson M.
        • Henderson S.
        • et al.
        The Mental Health of Australians. Commonwealth Department of Health and Aged Care, Canberra, Australia1999
        • Barrett P.M.
        • Rapee R.M.
        • Dadds M.R.
        • Ryan S.M.
        • et al.
        Family enhancement of cognitive style in anxious and aggressive children.
        J Abnorm Child Psychol. 1996; 24: 187-203
        • Beidel D.C.
        • Turner S.M.
        At risk for anxiety. I. Psychopathology in the offspring of anxious parents.
        J Am Acad Child Adolesc Psychiatry. 1997; 36: 918-924
        • Bruch M.A.
        • Heimberg R.G.
        Differences in perceptions of parental and personal characteristics between generalized and nongeneralized social phobics.
        J Anx Disord. 1994; 8: 155-168
        • Buss A.H.
        • Plomin R.
        Temperament: Early Developing Personality Traits. Lawrence Erlbaum Associates, Hillsdale, NJ1984
        • Caspi A.
        • Moffitt T.E.
        • Newman D.L.
        • Silva P.A.
        • et al.
        Behavioral observations at age 3 years predict adult psychiatric disorders.
        Arch Gen Psychiatry. 1996; 53: 1033-1039
        • Cook M.
        • Mineka S.
        Observational conditioning of fear to fear-relevant versus fear-irrelevant stimuli in Rhesus monkeys.
        J Abnorm Psychol. 1989; 98: 448-459
        • Crowe R.R.
        • Noyes R.
        • Pauls D.L.
        • Slymen D.
        • et al.
        A family study of panic disorder.
        Arch Gen Psychiatry. 1983; 40: 1065-1069
        • Dadds M.R.
        • Barrett P.M.
        • Rapee R.M.
        • Ryan S.M.
        • et al.
        Family process and child anxiety and aggression.
        J Abnorm Child Psychol. 1996; 24: 715-734
        • Ehlers A.
        Somatic symptoms and panic attacks.
        Behav Res Ther. 1993; 31: 269-278
        • Eley T.C.
        General genes.
        Curr Dir Psychol Sci. 1997; 6: 90-95
        • Eley T.C.
        Behavioral genetics as a tool for developmental psychology.
        Clin Child Fam Psychol Rev. 1999; 2: 21-36
        • Engfer A.
        Antecedents and consequences of shyness in boys and girls.
        in: Rubin K.H. Asendorpf J.B. Social Withdrawal, Inhibition, and Shyness in Children. Lawrence Erlbaum Associates, Hillsdale, NJ1993: 49-79
        • Fyer A.J.
        • Mannuzza S.
        • Chapman T.F.
        • Martin L.Y.
        • Klein D.F.
        • et al.
        Specificity in familial aggregation of phobic disorders.
        Arch Gen Psychiatry. 1995; 52: 564-573
        • Gerull F.C.
        • Rapee R.M.
        Mother knows best.
        Behav Res Ther. 2002; 40: 279-287
        • Goldin P.C.
        A review of children’s reports of parent behaviors.
        Psychol Bull. 1969; 71: 222-236
        • Goldsmith H.H.
        • Gottesman I.I.
        Origins of variation in behavioral style.
        Child Dev. 1981; 52: 91-103
        • Gould R.A.
        • Otto M.W.
        • Pollack M.H.
        • et al.
        A meta-analysis of treatment outcome for panic disorder.
        Clin Psychol Rev. 1995; 15: 819-844
        • Gould R.A.
        • Otto M.W.
        • Pollack M.H.
        • Yap L.
        • et al.
        Cognitive behavioral and pharmacological treatment of generalized anxiety disorder.
        Behav Ther. 1997; 28: 285-305
        • Greenberg P.E.
        • Sisitsky T.
        • Kessler R.C.
        • Finkelstein S.N.
        • Berndt E.R.
        • Davidson J.R.T.
        • et al.
        The economic burden of anxiety disorders in the 1990s.
        J Clin Psychiatry. 1999; 60: 427-435
        • Hirshfeld D.R.
        • Biederman J.
        • Brody L.
        • Faraone S.V.
        • et al.
        Associations between expressed emotion and child behavioral inhibition and psychopathology.
        J Am Acad Child Adolesc Psychiatry. 1997; 36: 205-213
        • Hirshfeld D.R.
        • Rosenbaum J.F.
        • Biederman J.
        • Bolduc E.A.
        • Faraone S.V.
        • Snidman N.
        • et al.
        Stable behavioral inhibition and its association with anxiety disorder.
        J Am Acad Child Adolesc Psychiatry. 1992; 31: 103-111
        • Hudson J.L.
        • Rapee R.M.
        Parent–child interactions and anxiety disorders.
        Behav Res Ther. 2001; 39: 1411-1427
      1. Hudson JL, Rapee RM (in press-a): Parent–child interactions in clinically anxious children and their siblings. J Clin Child Adolesc Psychol

      2. Hudson JL, Rapee RM (in press-b): From anxious temperament to disorder: An etiological model of generalized anxiety disorder. In: Heimberg RG, Turk CL, Mennin DS, editors. Generalized anxiety disorder: Advances in research and practice. New York: Guilford Press

        • Kagan J.
        • Reznick J.S.
        • Clarke C.
        • Snidman N.
        • Garcia-Coll C.
        • et al.
        Behavioral inhibition to the unfamiliar.
        Child Dev. 1984; 55: 2212-2225
        • Kagan J.
        • Snidman N.
        Early childhood predictors of adult anxiety disorders.
        Biol Psychiatry. 1999; 46: 1536-1541
        • Kagan J.
        • Snidman N.
        • Arcus D.
        • Reznick J.S.
        • et al.
        Galen’s Prophecy: Temperament in Human Nature. Basic Books, New York1994
        • Kagan J.
        • Snidman N.
        • Zentner M.
        • Peterson E.
        • et al.
        Infant temperament and anxious symptoms in school age children.
        Dev Psychopathol. 1999; 11: 209-224
        • Kendler K.S.
        • Heath A.
        • Martin N.G.
        • Eaves L.J.
        • et al.
        Symptoms of anxiety and depression in a volunteer twin population.
        Arch Gen Psychiatry. 1986; 43: 213-221
        • Kendler K.S.
        • Walters E.E.
        • Neale M.C.
        • Kessler R.C.
        • Heath A.C.
        • Eaves L.J.
        • et al.
        The structure of the genetic and environmental risk factors for six major psychiatric disorders in women.
        Arch Gen Psychiatry. 1995; 52: 374-383
        • Krohne H.W.
        • Gutenberg J.
        Parental childrearing and anxiety development.
        in: Hurrelmann K. Lovel F. Health Hazards in Adolescence. Walter de Gruyter, Berlin1990: 115-130
        • Krohne H.W.
        • Hock M.
        Relationships between restrictive mother–child interactions and anxiety of the child.
        Anx Res. 1991; 4: 109-124
        • LaFreniere P.J.
        • Capuano F.
        Preventive intervention as a means of clarifying direction of effects in socialization.
        Dev Psychopathol. 1997; 9: 551-564
        • Last C.G.
        • Hersen M.
        • Kazdin A.E.
        • Francis G.
        • Grubb H.J.
        • et al.
        Psychiatric illness in the mothers of anxious children.
        Am J Psychiatry. 1987; 144: 1580-1583
        • Magana A.B.
        • Goldstein M.J.
        • Karno M.
        • Miklowitz D.J.
        • Jenkins J.
        • Falloon I.R.H.
        • et al.
        A brief method for assessing expressed emotion in relatives of psychiatric patients.
        Psychiatry Res. 1986; 17: 203-212
        • Massion A.O.
        • Warshaw M.G.
        • Keller M.B.
        • et al.
        Quality of life and psychiatric morbidity in panic disorder and generalized anxiety disorder.
        Am J Psychiatry. 1993; 150: 600-607
        • Mathers C.
        • Vos T.
        • Stevenson C.
        • et al.
        The Burden of Disease and Injury in Australia. Australian Institute of Health and Welfare, Canberra, Australia1999 (AIHW cat. no. PHE 17)
        • Menzies R.G.
        • Clarke J.C.
        The etiology of phobias.
        Clin Psychol Rev. 1995; 15: 23-48
        • Merckelbach H.
        • de Jong P.
        • Muris P.
        • van den Hout M.A.
        • et al.
        The etiology of specific phobias.
        Clin Psychol Rev. 1996; 16: 337-361
        • Mrazek P.J.
        • Haggerty R.J.
        Reducing Risks for Mental Disorders. National Academy Press, Washington, DC1994
        • Muris P.
        • Steerneman P.
        • Merckelbach H.
        • Meesters C.
        • et al.
        The role of parental fearfulness and modelling in children’s fear.
        Behav Res Ther. 1996; 34: 265-268
        • Murray C.J.L.
        • Lopez A.D.
        The Global Burden of Disease: A Comprehensive Assessment of Mortality and Disability from Diseases Injuries and Risk Factors in 1990 and Projected to 2020. Harvard University Press, Cambridge, MA1996
        • Norton G.R.
        • McLeod L.
        • Guertin J.
        • Hewitt P.L.
        • Walker J.R.
        • Stein M.B.
        • et al.
        Panic disorder or social phobia.
        Behav Res Ther. 1996; 34: 273-276
        • Noyes Jr, R.
        • Clarkson C.
        • Crowe R.R.
        • Yates W.R.
        • McChesney C.M.
        • et al.
        A family study of generalized anxiety disorder.
        Am J Psychiatry. 1987; 144: 1019-1024
        • Ollendick T.H.
        • King N.J.
        Origins of childhood fears.
        Behav Res Ther. 1991; 29: 117-123
        • Owen N.
        • Bauman A.
        The descriptive epidemiology of a sedentary lifestyle in Australians.
        Int J Epidemiol. 1992; 21: 305-309
        • Parker G.
        A decade of research.
        Soc Psychiatry Psychiatr Epidemiol. 1990; 25: 281-282
        • Pine D.S.
        • Cohen P.
        • Gurley D.
        • Brook J.
        • Ma Y.
        • et al.
        The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders.
        Arch Gen Psychiatry. 1998; 55: 56-64
        • Plomin R.
        Childhood temperament.
        Adv Clin Child Psychol. 1983; 6: 45-92
        • Prior M.
        Childhood temperament.
        J Child Psychol Psychiatry. 1992; 33: 249-279
        • Prior M.
        • Smart D.
        • Sanson A.
        • Oberklaid F.
        • et al.
        Does shy-inhibited temperament in childhood lead to anxiety problems in adolescence?.
        J Am Acad Child Adolesc Psychiatry. 2000; 39: 461-468
        • Rachman S.
        The conditioning theory of fear acquisition.
        Behav Res Ther. 1977; 15: 375-387
        • Rapee R.M.
        Potential role of childrearing practices in the development of anxiety and depression.
        Clin Psychol Rev. 1997; 17: 47-67
        • Rapee R.M.
        The development of generalised anxiety.
        in: Vasey M.W. Dadds M.R. The Developmental Psychopathology of Anxiety. Oxford University Press, New York2001: 481-504
      3. Rapee RM, Szollos AA (in submission): Developmental antecedents of clinical anxiety in childhood

      4. Rapee RM, Tolhurst Z (2000, November): Expressed emotion in the mothers of children with anxiety disorders. Paper presented at the Association for the Advancement for Behavior Therapy Annual Congress, New Orleans, Louisiana

        • Robinson J.L.
        • Kagan J.
        • Reznick J.S.
        • Corley R.
        • et al.
        The heritability of inhibited and uninhibited behavior.
        Dev Psychol. 1992; 28: 1030-1037
        • Rosenbaum J.F.
        • Biederman J.
        • Bolduc-Murphy B.A.
        • Faraone S.V.
        • Chaloff J.
        • Hirshfeld D.R.
        • Kagan J.
        • et al.
        Behavioral inhibition in childhood.
        Harvard Rev Psychiatry. 1993; 1: 2-16
        • Roy-Byrne P.P.
        • Katon W.
        Generalized anxiety disorder in primary care.
        J Clin Psychiatry. 1997; 58: 34-38
        • Rubin K.H.
        • Asendorpf J.B.
        Social withdrawal inhibition and shyness in childhood.
        in: Rubin K.H. Asendorpf J.B. Social Withdrawal Inhibition and Shyness in Children. Lawrence Erlbaum Associates, Hillsdale, NJ1993: 3-17
        • Rubin K.H.
        • Mills R.S.L.
        Maternal beliefs about adaptive and maladaptive social behaviors in normal aggressive and withdrawn preschoolers.
        J Abnorm Child Psychol. 1990; 18: 419-435
        • Rubin K.H.
        • Mills R.S.L.
        Conceptualizing developmental pathways to internalizing disorders in childhood.
        Can J Behav Sci. 1991; 23: 300-317
        • Sanson A.
        • Pedlow R.
        • Cann W.
        • Prior M.
        • Oberklaid F.
        • et al.
        Shyness ratings: Stability and correlates in early childhood.
        Int J Behav Dev. 1996; 19: 705-724
        • Schwartz C.E.
        • Snidman N.
        • Kagan J.
        • et al.
        Adolescent social anxiety as an outcome of inhibited temperament in childhood.
        J Am Acad Child Adolesc Psychiatry. 1999; 38: 1008-1015
      5. Silverman WK, Albano AM, (1996): The Anxiety Disorders Interview Schedule for Children—IV (Child and Parent Versions). San Antonio, TX: Psychological Corporation

        • Siqueland L.
        • Kendall P.C.
        • Steinberg L.
        • et al.
        Anxiety in children.
        J Clin Child Psychol. 1996; 25: 225-237
        • Spence S.H.
        Prevention strategies.
        in: Vasey M.W. Dadds M.R. The Developmental Psychopathology of Anxiety. Oxford University Press, New York2001: 325-354
        • Thomas A.
        • Chess S.
        Temperament and Development. Brunner/Mazel, New York1977
        • Vasey M.W.
        • Dadds M.R.
        The Developmental Psychopathology of Anxiety. Oxford University Press, New York2001
        • Verhulst F.C.
        • van der Ende J.
        • Ferdinand R.F.
        • Kasius M.C.
        • et al.
        The prevalence of DSM-III-R diagnoses in a national sample of Dutch adolescents.
        Arch Gen Psychiatry. 1997; 54: 329-336
        • Watt M.C.
        • Stewart S.H.
        Anxiety sensitivity mediates the relationships between childhood learning experiences and elevated hypochondriacal concerns in young adulthood.
        J Psychosom Res. 2000; 49: 107-118
        • Weisz J.R.
        • Weiss B.
        Studying the “referability” of child clinical problems.
        J Consult Clin Psychol. 1991; 59: 266-273