Abstract
Background: Perinatal anoxia leads to persistent behavioral and neurochemical alterations
suggestive of sensitized dopaminergic function. Because astrocytic basic fibroblast
growth factor (bFGF) activity in the midbrain dopaminergic cell body region is required
for the development of enduring changes in dopaminergic function induced by stimulant
drugs, we investigated the effects of intrauterine anoxia on astrocytic bFGF expression
in dopaminergic regions at 2 weeks of age and after a stress manipulation in adults.
Methods: We examined bFGF immunoreactivity in dopaminergic regions of young and adult
rats born by cesarean section, cesarean section + 15 min of intrauterine anoxia, or
vaginally. bFGF immunoreactivity was also assessed before and after tail-pinch stress
in adult animals exposed to the same perinatal interventions.
Results: Perinatal anoxia produced persistent decreases in basal bFGF immunoreactivity
in the ventral tegmental area (VTA), but enhanced the effect of stress on VTA bFGF
immunoreactivity.
Conclusions: Perinatal anoxia has enduring effects on VTA bFGF immunoreactivity and
influences adult neuroadaptations to stress. The mechanisms whereby perinatal anoxia
alters dopaminergic function may be similar to those responsible for the development
of sensitization to stimulant drugs and may involve bFGF.
Keywords
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Article info
Publication history
Accepted:
February 1,
2002
Received in revised form:
January 23,
2002
Received:
October 26,
2001
Identification
Copyright
© 2002 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
