Abstract
Background: Our goal was to identify brain structures involved in anticipatory anxiety
in panic disorder (PD) patients compared to control subjects.
Methods: Seventeen PD patients and 21 healthy control subjects were studied with H215O positron emission tomography scan, before and after a pentagastrin challenge.
Results: During anticipatory anxiety we found hypoactivity in the precentral gyrus,
the inferior frontal gyrus, the right amygdala, and the anterior insula in PD patients
compared to control subjects. Hyperactivity in patients compared to control subjects
was observed in the parahippocampal gyrus, the superior temporal lobe, the hypothalamus,
the anterior cingulate gyrus, and the midbrain. After the challenge, the patients
showed decreases compared to the control subjects in the precentral gyrus, the inferior
frontal gyrus, and the anterior insula. Regions of increased activity in the patients
compared to the control subjects were the parahippocampal gyrus, the superior temporal
lobe, the anterior cingulate gyrus, and the midbrain.
Conclusions: The pattern of regional cerebral blood flow activations and deactivations
we observed both before and after the pentagastrin challenge was the same, although
different in intensity. During anticipatory anxiety more voxels were (de)activated
than during rest after the challenge.
Keywords
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Article info
Publication history
Accepted:
February 11,
2002
Received in revised form:
January 9,
2002
Received:
July 24,
2001
Identification
Copyright
© 2002 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
