Abstract
Background: The role of neuronal nicotinic receptors in the etiology and pathophysiology
of schizophrenia has been suggested by postmortem findings as well as by linkage analysis
implicating chromosome 15q14, the region where the α-7 nicotinic receptor gene is
located. In addition, drug probe studies show that acute nicotine administration reverses
sensory gating and eye-tracking deficits associated with the genetic liability for
schizophrenia. The purpose of the current study was to examine the effects of acute
administration of nicotine on specific measures of smooth pursuit eye movements and
visual attention.
Methods: Twenty nine subjects with schizophrenia (15 smokers and 14 nonsmokers), and
26 healthy comparison subjects (15 smokers and 11 nonsmokers) completed testing. The
effects of 1 mg of nicotine, administered by nasal spray, on smooth pursuit initiation,
pursuit maintenance, and predictive pursuit were examined.
Results: Nicotine significantly improved eye acceleration during smooth pursuit initiation
in both smoker and nonsmoker patients but had no effects in healthy subjects. The
fact that patient initiation eye acceleration in response to nicotine was significantly
higher than in healthy subjects suggests that the lack of effect in healthy subjects
was not due to ceiling effects. Nicotine significantly improved pursuit gain during
maintenance at a target velocity of 18.7 deg/sec. There were no effects of nicotine
on visually guided and memory saccades, or visual attention (d′ from a continuous
performance task).
Conclusions: Nicotine showed differential effects in schizophrenic patients compared
to healthy subjects. These effects of nicotine were unlikely the result of differences
in vigilance or sustained attention, because saccadic peak velocity, a sensitive measure
of vigilance, and continuous performance task measures were not affected by nicotine.
These findings are not thought to be an artifact of nicotine withdrawal effects at
baseline, because the abstinence period was very short, and there were similar effects
of nicotine on initiation in nonsmoker patients. These findings suggest an abnormality
in neuronal nicotinic system functioning in schizophrenic patients.
Keywords
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Article info
Publication history
Accepted:
January 25,
2002
Received in revised form:
January 8,
2002
Received:
September 28,
2001
Identification
Copyright
© 2002 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.