High-dose ascorbic acid increases intercourse frequency and improves mood: a randomized controlled clinical trial

  • Stuart Brody
    Address reprint requests to: Stuart Brody, Ph.D., FPP/Uni-Trier, Saarbruecker Strasse 46 54290 Trier, Germany
    Center for and the Psychosomatic and Psychobiological Research, University of Trier, Germany; and the Institute for Medical Psychology and Behavioral Neurobiology, University of Tübingen, Germany
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      Background: Ascorbic acid (AA) modulates catecholaminergic activity, decreases stress reactivity, approach anxiety and prolactin release, improves vascular function, and increases oxytocin release. These processes are relevant to sexual behavior and mood.
      Methods: In this randomized double-blind, placebo-controlled 14 day trial of sustained-release AA (42 healthy young adults; 3000 mg/day Cetebe) and placebo (39 healthy young adults), subjects with partners recorded penile-vaginal intercourse (FSI), noncoital partner sex, and masturbation in daily diaries, and also completed the Beck Depression Inventory before and after the trial.
      Results: The AA group reported greater FSI (but, as hypothesized, not other sexual behavior) frequency, an effect most prominent in subjects not cohabiting with their sexual partner, and in women. The AA but not placebo group also experienced a decrease in Beck Depression scores.
      Conclusions: AA appears to increase FSI, and the differential benefit to noncohabitants suggests that a central activation or disinhibition, rather than peripheral mechanism may be responsible.


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        • Apt C.
        • Hurlbert D.F.
        The female sensation seeker and marital sexuality.
        J Sex Marital Ther. 1992; 18: 315-324
        • Brody S.
        Sex at risk. Transaction, New Brunswick, NJ1997
        • Brody S.
        • Preut R.
        • Schommer K.
        • Schürmeyer T.H.
        A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress.
        Psychopharmacology. 2002; 159: 319-324
        • Brody S.
        • Veit R.
        • Rau H.
        A preliminary report relating frequency of vaginal intercourse to heart rate variability, Valsalva ratio, blood pressure, and cohabitation status.
        Biol Psychol. 2000; 52: 251-257
        • Cocchi P.
        • Silenzi M.
        • Calabri G.
        • Salvi G.
        Antidepressant effect of vitamin C.
        Pediatrics. 1980; 65: 862-863
        • Exton M.S.
        • Bindert A.
        • Krüger T.
        • Scheller F.
        • Hartmann W.
        • Schedlowski M.
        Cardiovascular and endocrine alterations after masturbation-induced orgasm in women.
        Psychosom Med. 1999; 61: 280-289
        • Exton M.S.
        • Krüger T.H.C.
        • Koch M.
        • Paulson E.
        • Knapp W.
        • Hartmann U.
        • Schledlowski M.
        Coitus-induced orgasm stimulates prolactin secretion in healthy subjects.
        Psychoneuroendocrinology. 2001; 26: 287-294
        • Eysenck H.J.
        Eysenck Persönlichkeits Inventar. Verlag für Psychologie, Göttingen1974
        • Girbe F.
        • Ramassamy C.
        • Piton C.
        • Costentin J.
        Ascorbic acid increases synaptosomal potassium-induced dopamine release.
        Neuroreport. 1994; 9: 1027-1029
        • Gokce N.
        • Keaney Jr, J.F.
        • Frei B.
        • Holbrook M.
        • Olesiak M.
        • Zachariah B.J.
        • et al.
        Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease.
        Circulation. 1999; 99: 3234-3240
        • Gulley J.M.
        • Rebec G.V.
        Modulatory effects of ascorbate, alone or with haloperidol, on a lever-release conditioned avoidance response task.
        Pharmacol Biochem Behav. 1999; 63: 125-129
        • Hautzinger M.
        • Bailer M.
        • Worall H.
        • Keller F.
        Beck-Depressions-Inventar (BDI). Huber, Bern1994
        • Kimelberg H.K.
        • Goderie S.K.
        Effect of ascorbate on Na(+)-independent and Na(+)-dependent uptake of [3H]norepinephrine by rat primary astrocyte cultures from neonatal rat cerebral cortex.
        Brain Res. 1993; 602: 41-44
        • Luck M.R.
        • Jungclas B.
        Catecholamines and ascorbic acid as stimulators of bovine ovarian oxytocin secretion.
        J Endocrinol. 1987; 114: 423-430
        • Nurse B.
        • Russell V.A.
        • Taljaard J.J.F.
        Effect of chronic desipramine treatment on adrenoreceptor modulation of [3H]dopamine release from rat nucleus accumbens slices.
        Brain Res. 1985; 334: 235-242
        • Paterson I.A.
        • Hertz L.
        Sodium-independent transport of noradrenaline in mouse and rat astrocytes in primary culture.
        J Neurosci Res. 1989; 23: 71-77
        • Pierce R.C.
        • Rowlett J.K.
        • Rebec G.V.
        • Bardo M.T.
        Ascorbate potentiates amphetamine-induced conditioned place preference and forebrain dopamine release in rats.
        Brain Res. 1995; 688: 21-26
        • Rebec G.V.
        • Pierce R.C.
        A vitamin as neuromodulator.
        Prog Neurobiol. 1994; 43: 537-565
        • Satterlee D.G.
        • Jones R.B.
        • Ryder F.H.
        Effects of Vitamin C supplementation on the adrenocortical and tonic immobility fear reactions of Japanese quail genetically selected for high corticosterone response to stress.
        Appl Anim Behav Sci. 1993; 35: 347-357
        • Seitz G.
        • Gebhardt S.
        • Beck J.F.
        • Bohm W.
        • Lode H.N.
        • Niethammer D.
        • Bruchelt G.
        Ascorbic acid stimulates DOPA synthesis and tyrosine hydroxylase gene expression in the human neuroblastoma cell line SK-N-SH.
        Neurosci Lett. 1998; 244: 33-36
        • Sershen H.
        • Debler E.A.
        • Lajtha A.
        Effect of ascorbic acid on the synaptosomal uptake of [3H]MPP+, [3H]dopamine, and [14C]GABA.
        J Neurosci Res. 1987; 17: 298-301
        • Shin S.H.
        • Stirling R.G.
        • Hanna S.
        • Lim M.
        • Wilson J.X.
        Ascorbic acid potentiates the inhibitory effect of dopamine on prolactin release.
        Endocrinol Exp. 1990; 24: 151-158
        • Strobel A.
        • Wehr A.
        • Michel A.
        • Brocke B.
        Association between the dopamine D4 receptor (DRD4) exon III polymorphism and measures of novelty seeking in a german population.
        Mol Psychiatry. 1999; 4: 378-384
        • Wilkinson I.B.
        • Megson I.L.
        • MacCallum H.
        • Sogo N.
        • Cockcroft J.R.
        • Webb D.J.
        Oral vitamin C reduces arterial stiffness and platelet aggregation in humans.
        J Cardiovasc Pharmacol. 1999; 34: 690-693