Abstract
Background: We previously reported that stress-related release of cortisol and neuropeptide-Y
(NPY) were significantly and positively associated in U.S. Army soldiers participating
in survival training. Furthermore, greater levels of NPY were observed in individuals
exhibiting fewer psychologic symptoms of dissociation during stress. This study tested
whether these findings would be replicated in a sample of U.S. Navy personnel participating
in survival school training.
Methods: Psychologic as well as salivary and plasma hormone indices were assessed
in 25 active duty personnel before, during, and 24 hours after exposure to U.S. Navy
survival school stress.
Results: Cortisol and NPY were significantly and positively associated during stress
and 24 hours after stress; NPY and norepinephrine (NE) were significantly and positively
related during and 24 hours after stress. There was a significant, negative relationship
between psychologic distress and NPY release during stress. Finally, psychologic symptoms
of dissociation reported at baseline predicted significantly less NPY release during stress.
Conclusions: These data replicate our previous studies demonstrating that acute stress
elicits NPY release and that this release is positively associated with cortisol and
NE release. These data also replicate our previous finding that greater levels of
NPY release are associated with less psychologic distress suggesting that NPY confers
anxiolytic activity.
Keywords
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Article info
Publication history
Accepted:
December 19,
2001
Received in revised form:
November 21,
2001
Received:
May 17,
2001
Identification
Copyright
© 2002 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
