Abstract
Genomic imprinting is an epigenetic phenomenon affecting a small number of genes that
leads to expression from only one parental allele. Several imprinted genes are important
for neurologic development and function and several neurobehavioral disorders are
caused by genetic defects involving imprinted genes. For some genes, the imprinting
is tissue specific, leading to biallelic expression in some tissues and monoallelic
expression in other tissues. Defects involving these genes may produce one restricted
phenotype due to loss of expression of the gene product in tissues where the gene
is imprinted and, in some instances, a second phenotype due to haploinsufficiency
of the gene product in tissues where it is biallelically expressed.
Keywords
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Article info
Publication history
Accepted:
September 12,
2001
Received in revised form:
August 31,
2001
Received:
July 9,
2001
Footnotes
☆This work was supported by the Division of Intramural Research of the National Institute of Diabetes, Digestive, and Kidney Diseases.
Identification
Copyright
© 2001 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
