Abstract
Background: Subgenual prefrontal cortex (SGPFC) volume reduction has been reported
in middle age adults with major depression (MD) or bipolar affective disorder. In
this study, the authors test the hypothesis that SGPFC reduction is present in adolescent
onset MD, and examine differences in the magnitude of reduction in younger versus
older women.
Methods: Subgenual prefrontal cortex volume was measured from T1 weighted MR images
in (1) 30 young women with early onset MD versus eight age-matched controls, and (2)
18 middle aged women with recurrent MD versus nine age- matched controls.
Results: Left SGPFC volume was reduced in adolescent and middle aged females with
depression. The magnitude of the difference between depressed and control groups (average
19% difference) was similar in younger and older women.
Conclusions: Left subgenual cingulate volume reductions are present in young women
with adolescent onset MD.
Keywords
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Article info
Publication history
Accepted:
August 14,
2001
Received in revised form:
July 11,
2001
Received:
September 21,
2000
Identification
Copyright
© 2002 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
