Abstract
Background: Reduced dopaminergic transmission has been implicated in the pathophysiology
of major depression. The aim of the present study was to measure striatal D2 receptor availability and amphetamineinduced dopamine release in nonpsychotic, unmedicated,
unipolar patients during an episode of major depression.
Methods: The striatal equilibrium specific to nonspecific partition coefficient (V3″) of the D2 receptor antagonist [123I]IBZM was measured with single photon emission computerized tomography before and
after amphetamine administration in 9 depressed subjects and 10 matched healthy control
subjects.
Results: No significant differences were observed in preamphetamine D2 receptor availability between depressed patients (0.73 ± 0.08) and control subjects
(0.78 ± 0.10, p = .23). Amphetamine-induced reduction in [123I]IBZM V3″ (ΔV3″) was similar in depressed patients (−9.8 ± 5.5%) and control subjects (−7.8 ± 2.5%,
p = .32). Amphetamine induced a transient improvement in symptomatology in depressed
patients, but this improvement did not correlate with [123I]IBZM ΔV3″.
Conclusions: This study did not replicate previously reported alterations in striatal
D2 receptor density in depressed patients and suggests that stimulant-induced dopamine
release is not altered in major depression.
Keywords
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Article info
Publication history
Accepted:
January 4,
2001
Received in revised form:
December 27,
2000
Received:
June 22,
2000
Identification
Copyright
© 2001 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
