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Pupillary and reaction time measures of sustained processing of negative information in depression

      Abstract

      Background: Disruptions of emotional information processing (i.e., attention to, memory for, and interpretation of emotional information) have been implicated in the onset and maintenance of depression. The research presented here investigated cognitive and psychophysiological features of a particularly promising correlate of depression: sustained processing of negative information 4–5 sec after an emotional stimulus.
      Methods: Pupil dilation data and reaction times were collected from 24 unmedicated depressed and 25 nondepressed adults in response to emotional processing tasks (lexical decision and valence identification) that employed idiosyncratically generated personally relevant and normed stimuli. Pupil dilation was used to index sustained cognitive processing devoted to stimuli.
      Results: Consistent with predictions, depressed individuals were especially slow to name the emotionality of positive information, and displayed greater sustained processing (pupil dilation) than nondepressed individuals when their attention was directed toward emotional aspects of information. Contrary to predictions, depressed participants did not dilate more to negative than positive stimuli, compared to nondepressed participants.
      Conclusions: These data suggest depressed individuals may not initially attend to emotional aspects of information but may continue to process them seconds after they have reacted to the information.

      Keywords

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      References

        • Ahern S.K
        • Beatty J
        Physiological signs of information processing vary with intelligence.
        Science. 1979; 205: 1289-1292
      1. American Psychiatric Association (1994): Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: American Psychiatric Press.

        • Beatty J
        Phasic not tonic pupillary responses vary with auditory vigilance performance.
        Psychophysiology. 1982; 19: 167-172
        • Beatty J
        Task-evoked pupillary responses, processing load, and the structure of processing resources.
        Psychol Bull. 1982; 91: 276-292
      2. Beck AT (1967): Depression: Clinical, Experimental, and Theoretical Aspects. New York: Hoeber.

        • Bower G
        Mood and memory.
        Am Psychol. 1981; 36: 129-148
        • Brown G
        • Kinderman S
        • Siegle G.J
        • Granholm E
        • Wong E.C
        • Buxton R.B
        Brain activation and pupil response during covert performance of the Stroop color word task.
        J Int Neuropsychol Soc. 1999; 5: 308-319
        • Challis B.H
        • Krane R.V
        Mood induction and the priming of semantic memory in a lexical decision task.
        Bull Psychonomic Soc. 1988; 26: 309-312
      3. Coles MGH, Gratton G, Kramer AF, Miller GA (1986): Principles of signal acquisition and analysis. In: Coles MGH, Donchin E, Porges SW, editors. Psychophysiology: Systems, Processes, and Applications. New York: Guilford.

      4. Fritz HL (1999): The role of rumination in adjustment to a first coronary event. Unpublished doctoral dissertation, Carnegie Mellon University, Pittsburgh.

        • Granholm E
        • Asarnow R.F
        • Sarkin A.J
        • Dykes K.L
        Pupillary responses index cognitive resource limitations.
        Psychophysiology. 1996; 33: 457-461
        • Hess E.H
        • Polt J.H
        Pupil size in relation to mental activity during simple problem solving.
        Science. 1964; 143: 1190-1192
        • Hill A.B
        • Kemp-Wheeler S.M
        The influence of anxiety on lexical and affective decision time for emotional words.
        Pers Individual Differences. 1989; 10: 1143-1149
        • Hyoenae J
        • Tommola J
        • Alaja A
        Pupil dilation as a measure of processing load in simultaneous interpretation and other language tasks.
        Q J Exp Psychol Hum Exp Psychol. 1995; 48: 598-612
        • Ingram R
        Toward an information processing analysis of depression.
        Cogn Ther Res. 1984; 8: 443-478
        • Jennings J.R
        • van der Molen M.W
        • Steinhauer S.R
        Preparing the heart, eye, and brain.
        Psychophysiology. 1998; 35: 90-98
        • Kahneman D
        • Beatty J
        Pupil diameter and load on memory.
        Science. 1966; 154: 1583-1585
      5. LeDoux J (1996): The Emotional Brain. New York: Simon and Schuster.

        • Lyubomirsky S
        • Caldwell N.D
        • Nolen-Hoeksema S
        Effects of ruminative and distracting responses to depressed mood on retrieval of autobiographical memories.
        J Pers Soc Psychol. 1998; 75: 166-177
      6. MacLeod C, Mathews AM (1991): Cognitive-experimental approaches to the emotional disorders. In: Martin PR, editor. Handbook of Behavior Therapy and Psychological Science: An Integrative Approach. New York: Pergamon, 116–150.

        • Macleod C
        • Mathews A.M
        • Tata P
        Attentional bias in emotional disorder.
        J Abnorm Psychol. 1986; 95: 15-20
        • Mathews A
        • Milroy R
        Processing of emotional meaning in anxiety.
        Cogn Emotion. 1994; 8: 535-553
        • Matt G
        • Vazquez C
        • Campbell W
        Mood-congruent recall of affectively toned stimuli.
        Clin Psychol Rev. 1992; 12: 227-255
        • Matthews G
        • Southall A
        Depression and the processing of emotional stimuli.
        Cogn Ther Res. 1991; 15: 283-302
      7. Maxwell SE, Delaney HD (1990): Designing Experiments and Analyzing Data. Belmont, CA: Wadsworth.

        • Mayberg H.S
        Limbic-cortical dysregulation.
        J Neuropsychiatr Clin Neurosci. 1997; 9: 471-481
        • Metcalfe J
        • Mischel W
        A hot/cool-system analysis of delay of gratification.
        Psychol Rev. 1999; 106: 3-19
      8. Nesselroade JR, Cattell RB, editors (1988): Handbook of Multivariate Experimental Psychology, 2nd ed. New York: Plenum Press.

        • Nolen-Hoeksema S
        • Morrow J
        • Fredrickson B.L
        Response styles and the duration of episodes of depressed mood.
        J Abnorm Psychol. 1993; 102: 20-28
        • Ratcliff R
        Methods for dealing with reaction time outliers.
        Psychol Bull. 1993; 114: 510-532
      9. Ruiz Caballero JA, Bermudez Moreno J (1992): Individual differences in depression, induced mood, and perception of emotionally toned words. Eur J Pers 6:215–224.

        • Segal Z.V
        • Gemar M
        • Truchon C
        • Guirguis M
        • Horowitz L.M
        A priming methodology for studying self-representation in major depressive disorder.
        J Abnorm Psychol. 1995; 104: 205-213
        • Semmlow J
        • Stark L
        Pupil movements to light and accommodative stimulation.
        Vis Res. 1973; 13: 1087-1100
      10. Siegle GJ (1999): Cognitive and physiological aspects of attention to personally relevant negative information in depression. Unpublished doctoral disseration, San Diego State University, San Diego.

      11. Siegle GJ (1999): A neural network model of attention biases in depression. In: Reggia, JA, Ruppin E, Glanzman DL, editors, Disorders of Brain, Behavior, and Cognition: The Neurocomputational Perspective. New York: Elsevier, 415–441.

      12. Siegle GJ. The Balanced Affective Word List Creation Program. Available at: http://www.sci.sdsu.edu/CAL/wordlist/. Accessed October 24, 2000.

      13. Siegle GJ, Ingram RE, Matt GE (in press): Affective interference: Explanation for negative information processing biases in dysphoria? Cognitive Therapy and Research.

      14. Spitzer RL, Williams JB, Gibbon M, First MB (1992): The Structured Clinical Interview for DSM-III-R (SCID): I. History, rationale, and description. Arch Gen Psychiatry 49:624–629.

      15. Steinhauer SR, Hakerem G (1992): The pupillary response in cognitive psychophysiology and schizophrenia. In: Friedman D, Bruder GE, editors. Psychophysiology and Experimental Psychopathology: A Tribute to Samuel Sutton. New York: New York Academy of Sciences, 182–204.

        • Williams J.M.G
        • Mathews A
        • MacLeod C
        The emotional Stroop task and psychopathology.
        Psychol Bull. 1996; 120: 3-24
      16. Williams JMG, Oaksford M (1992): Cognitive science, anxiety, and depression: From experiments to connectionism. In: Stein DJ, Young JE, editors. Cognitive Science and the Clinical Disorders. San Diego: Academic Press.