Editorial| Volume 48, ISSUE 8, P713-714, October 15, 2000

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Structural plasticity: cause, result, or correlate of depression

      The articles in this issue of Biological Psychiatry are derived from oral presentations at a conference, “Depression in the 21st Century: New Insight into Drug Development and Neurobiology,” held February 2–22, 2000 in Dana Point, California. The speakers represented a range of clinical practitioners, pathologists, and preclinical investigators, with strong focus on the neurobiology of mood disorders, as well as a few basic scientists like myself who had a strong interest in the field but little experience with directly relevant models. My comments here reflect a view of biological psychiatry from the perspective of a generalist observing a fast moving field, integrating basic observations in neurobiology with clinically defined problems.
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        • Drevets W.C.
        Neuroimaging studies of mood disorders.
        Biol Psychiatry. 2000; 48: 813-828
        • Duman R.S.
        • Malberg J.
        • Nakagawa S.
        • D’Sa C.
        Neuronal plasticity and survival in mood disorder.
        Biol Psychiatry. 2000; 48: 732-739
        • Fujita M.
        • Charney D.S.
        • Innis R.B.
        Imaging serotonergic neurotransmission in depression.
        Biol Psychiatry. 2000; 48: 801-812
        • Gould E.
        • Tanapat P.
        • Rydel T.
        • Hastings N.
        Regulation of hippocampal neurogenesis in adulthood.
        Biol Psychiatry. 2000; 48: 715-720
        • Kaufman J.
        • Plotsky P.M.
        • Nemeroff C.B.
        • Charney D.S.
        Effects of early adverse experiences on brain structure and function.
        Biol Psychiatry. 2000; 48: 778-790
        • Manji H.K.
        • Moore G.J.
        • Chen G.
        Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers.
        Biol Psychiatry. 2000; 48: 740-754
        • Mayberg H.S.
        • Brannan S.
        • Tekell J.L.
        • Silva J.A.
        • Mahurin R.K.
        • McGinnis S.
        • Jerabek P.
        Regional metabolic effects of fluoxetine in major depression.
        Biol Psychiatry. 2000; 48: 830-843
        • McEwen B.S.
        Effects of adverse experiences for brain structure and function.
        Biol Psychiatry. 2000; 48: 721-731
        • Rajkowska G.
        Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells.
        Biol Psychiatry. 2000; 48: 766-777
        • Sapolsky R.M.
        The possibility of neurotoxicity in the hippocampus in major depression.
        Biol Psychiatry. 2000; 48: 755-765
        • Sheline Y.I.
        3D MRI studies of neuroanatomic changes in unipolar major depression.
        Biol Psychiatry. 2000; 48: 791-800