Editorial| Volume 48, ISSUE 6, P433-435, September 15, 2000

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On clinical trials in psychiatry

      The randomized controlled clinical trial is still a relatively new technology for assessing therapeutic interventions, yet innovations in the design and analysis of clinical trials in psychiatry have lagged behind other areas of the biomedical sciences. This delay in the advancement of the science and practice of psychiatric clinical trials is due in part to the inability, dating back to the 1950s, to solve the problem of the unreliability of psychiatric diagnosis and to the inability of psychiatric researchers to develop common agreed-upon outcome measures. Even though advances have been made in diagnosis and measurement, the existence of these and other methodological problems continues to contribute to the limited success of acute-phase efficacy trials in psychiatry. For example, in depression,
      • Thase M.E.
      How should efficacy be evaluated in randomized clinical trials of treatments for depression?.
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