Reduced binding to the serotonin transporter (5-HTT) in unaffected relatives of patients with manic–depressive illness has been recently reported as a hint of a putative trait marker for the disease by
Leboyer et al 1999. We offer a few comments and views on this.
- Leboyer M.
- Quintin P.
- Manivet P.
- Varoquaux O.
- Allilaire J.-F.
- Launay J.-M.
Decreased serotonin transporter binding in unaffected relatives of manic depressive patients.
Biol Psychiatry. 1999; 46: 1703-1706
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Biological Psychiatry
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- High anxiety.Science. 1996; 274: 1483-1484
- Genetic variation in the serotonin transporter region affects serotonin uptake in blood platelets.Am J Med Genet. 1999; 88: 83-87
- A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity.Biol Psychiatry. 2000; 47: 643-649
- Decreased serotonin transporter binding in unaffected relatives of manic depressive patients.Biol Psychiatry. 1999; 46: 1703-1706
- Effects of serotonin transporter promoter genotype on platelet serotonin transporter functionality in depressed children and adolescents.J Am Acad Child Adolesc Psychiatry. 1999; 38: 1396-1402
- Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine.Mol Psychiatry. 1998; 3: 508-511
© 2000 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.