Reduced binding to the serotonin transporter (5-HTT) in unaffected relatives of patients
with manic–depressive illness has been recently reported as a hint of a putative trait
marker for the disease by
Leboyer et al 1999
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References
- High anxiety.Science. 1996; 274: 1483-1484
- Genetic variation in the serotonin transporter region affects serotonin uptake in blood platelets.Am J Med Genet. 1999; 88: 83-87
- A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity.Biol Psychiatry. 2000; 47: 643-649
- Decreased serotonin transporter binding in unaffected relatives of manic depressive patients.Biol Psychiatry. 1999; 46: 1703-1706
- Effects of serotonin transporter promoter genotype on platelet serotonin transporter functionality in depressed children and adolescents.J Am Acad Child Adolesc Psychiatry. 1999; 38: 1396-1402
- Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine.Mol Psychiatry. 1998; 3: 508-511
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© 2000 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
