Commentary| Volume 48, ISSUE 6, P436-441, September 15, 2000

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Goals for research on bipolar disorder: the view from NIMH

      Bipolar disorder is common (affecting an estimated 1.5% of the adult population), serious, disabling, and inadequately researched. A high priority of the National Institute of Mental Health (NIMH) is to encourage both basic and clinical investigators to focus their research efforts on bipolar disorder. In this overview, I focus on six areas in which urgent questions and opportunities stand out: genetics, the mechanisms of mood regulation in the brain, animal models, pharmacologic treatment development, psychosocial interventions, and clinical trials. I will not discuss areas in which research is on a steady, successful course, and thus less in need of intervention.
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