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Brief report| Volume 48, ISSUE 4, P319-322, August 15, 2000

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Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders

  • Frank Bellivier
    Correspondence
    Address reprint requests to Frank Bellivier, Hôpital Henri Mondor, Service de psychiatrie Adulte, 51, avenue du Mal de Lattre de Tassigny, 94010 CRETEIL cedex, France
    Affiliations
    Service de Psychiatrie Adulte (Pr Rouillon), Hôpital Henri Mondor et Albert Chenevier, Assistance Publique-Hôpitaux de Paris, Créteil, France (FB, AS, FR, ML)

    Unité Neurobiologie et psychiatrie (INSERM U513), Faculté de médecine de Créteil, Créteil, France (FB, MN-B, FR, ML)
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  • Andreı̈ Szöke
    Affiliations
    Service de Psychiatrie Adulte (Pr Rouillon), Hôpital Henri Mondor et Albert Chenevier, Assistance Publique-Hôpitaux de Paris, Créteil, France (FB, AS, FR, ML)
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  • Chantal Henry
    Affiliations
    Service de Psychiatrie Adulte (Pr M. Bourgeois), Hôpital Charles Perrens, Bordeaux, France (CH, JL)
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  • Jérome Lacoste
    Affiliations
    Service de Psychiatrie Adulte (Pr M. Bourgeois), Hôpital Charles Perrens, Bordeaux, France (CH, JL)
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  • Corinne Bottos
    Affiliations
    Laboratoire Central de Biochimie et de Biologie Moléculaire, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France (CB, J-ML, J-LL)
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  • Marika Nosten-Bertrand
    Affiliations
    Unité Neurobiologie et psychiatrie (INSERM U513), Faculté de médecine de Créteil, Créteil, France (FB, MN-B, FR, ML)
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  • Patrick Hardy
    Affiliations
    Service de Psychiatrie Adulte (Pr Feline), Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France (PH), France
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  • Frederic Rouillon
    Affiliations
    Service de Psychiatrie Adulte (Pr Rouillon), Hôpital Henri Mondor et Albert Chenevier, Assistance Publique-Hôpitaux de Paris, Créteil, France (FB, AS, FR, ML)

    Unité Neurobiologie et psychiatrie (INSERM U513), Faculté de médecine de Créteil, Créteil, France (FB, MN-B, FR, ML)
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  • Jean-Marie Launay
    Affiliations
    Laboratoire Central de Biochimie et de Biologie Moléculaire, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France (CB, J-ML, J-LL)
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  • Jean-Louis Laplanche
    Affiliations
    Laboratoire Central de Biochimie et de Biologie Moléculaire, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France (CB, J-ML, J-LL)
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  • Marion Leboyer
    Affiliations
    Service de Psychiatrie Adulte (Pr Rouillon), Hôpital Henri Mondor et Albert Chenevier, Assistance Publique-Hôpitaux de Paris, Créteil, France (FB, AS, FR, ML)

    Unité Neurobiologie et psychiatrie (INSERM U513), Faculté de médecine de Créteil, Créteil, France (FB, MN-B, FR, ML)
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      Abstract

      Background: Genes involved in the serotonin system are major candidates in association studies of suicidal behavior. In this case–control study we investigated whether the serotonin transporter (5-HTT) gene encoding the protein responsible for the reuptake of serotonin from the synapse after its release from serotonergic neurons is a susceptibility factor for suicidal behavior.
      Methods: A functional polymorphism of the 5-HTT gene (a 44–base pair insertion/deletion in the 5-HTT–linked polymorphic region [5-HTTLPR]) was studied in a population of 237 consecutive patients with affective disorder (unipolar or bipolar) and 187 control subjects. Ninety-nine patients had attempted suicide at least once, of whom 26 made a violent attempt.
      Results: No association was found between the “s” allele of the 5-HTTLPR and suicide attempt; however, there was a significant difference in allele distributions between patients who had made violent suicide attempts and control subjects.
      Conclusions: A genetic variant of the 5-HTT gene may predispose individuals to violent suicidal behavior. The precise phenotype associated with the 5-HTT gene is unclear, and therefore further studies are required to replicate these findings.

      Keywords

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