Abstract
Schizophrenic and bipolar disorders are similar in several epidemiologic respects,
including age at onset, lifetime risk, course of illness, worldwide distribution,
risk for suicide, gender influence (men and women at equal risk for both groups of
disorders), and genetic susceptibility. Despite these similarities, schizophrenia
and bipolar disorders are typically considered to be separate entities, with distinguishing
clinical characteristics, non-overlapping etiologies, and distinct treatment regimens.
Over the past three decades, multiple family studies are consistent with greater nosologic
overlap than previously acknowledged. Molecular linkage studies (conducted during
the 1990s) reveal that some susceptibility loci may be common to both nosologic classes.
This indicates that our nosology will require substantial revision during the next
decade, to reflect this shared genetic susceptibility, as specific genes are identified.
Keywords
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Article info
Publication history
Accepted:
March 20,
2000
Received in revised form:
March 18,
2000
Received:
January 12,
2000
Identification
Copyright
© 2000 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
