It has been almost 30 years since Andreasson et al. demonstrated in 1987 an association between cannabis use and subsequent onset of
schizophrenia [reviewed in (
1
)]. There was a 15-year gap before any replications of their results were attempted.
However, as Gage et al. (
1
) point out, many longitudinal prospective studies have now been published. All four
investigations into the relationship between cannabis use and subsequent psychotic
illness reported a significant association; three studies that focused on cannabis
use and psychotic experiences also reported a significant association, and a further
three studies showed such an association, which became attenuated after adjustment
for confounders.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Biological PsychiatryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Association between cannabis and psychosis: Epidemiologic evidence.Biol Psychiatry. 2016; 79: 549-556
- Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment.J Psychopharmacol. 2013; 27: 19-27
- Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: A case-control study.Lancet Psychiatry. 2015; 2: 233-238
- Does tobacco use cause psychosis? Systematic review and meta-analysis.Lancet Psychiatry. 2015; 2: 718-725
- Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users.Schizophr Bull. 2014; 40: 1509-1517
- Differences in cannabis-related experiences between patients with a first episode of psychosis and controls [published online ahead of print Dec 16].Psychol Med. 2015;
- Continued versus discontinued cannabis use in patients with psychosis: A systematic review and meta-analysis [published online ahead of print Jan 14].Lancet Psychiatry. 2016;
- AKT1 genotype moderates the acute psychotomimetic effects of naturalistically smoked cannabis in young cannabis smokers [published online ahead of print Feb 16].Transl Psychiatry. 2016; 6 (http://dx.doi.org/10.1038/tp.2015.219): e738
- Interaction between functional genetic variation of DRD2 and cannabis use on risk of psychosis.Schizophr Bull. 2015; 41: 1171-1182
- Different dopaminergic abnormalities underlie cannabis dependence and cannabis-induced psychosis.Biol Psychiatry. 2014; 75: 430-431
Article info
Publication history
Accepted:
February 8,
2016
Received in revised form:
February 6,
2016
Received:
February 2,
2016
Identification
Copyright
© 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
