Background
Voxel-based analysis of diffusion tensor magnetic resonance imaging (DTI) data was
used to examine white matter integrity in adolescents with early-onset schizophrenia
(EOS), defined as schizophrenia beginning before the 18th birthday.
Methods
Nineteen patients with EOS, aged 13 to 19, were compared with 20 healthy volunteers
matched for age, gender, and parental socioeconomic status. Diffusion tensor magnetic
resonance imaging data were acquired on a GE Signa NVi 1.5 Tesla system (General Electric,
Milwaukee, Wisconsin). Maps of fractional anisotropy (FA) were registered into standard
space, and group differences were examined using a nonparametric statistical approach.
Results
In comparison with healthy participants, EOS patients had significantly lower FA in
the white matter of the parietal association cortex bilaterally and in the left middle
cerebellar penduncle. No areas with significantly higher FA in patients were identified.
Conclusions
Parietal and cerebellar white matter abnormalities may contribute to the emergence
of psychotic symptoms in adolescence.
Key Words
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Article info
Publication history
Published online: July 28, 2007
Accepted:
May 22,
2007
Received in revised form:
May 17,
2007
Received:
February 27,
2007
Identification
Copyright
© 2008 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
