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Validity of the Executive Function Theory of Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Review

      One of the most prominent neuropsychologic theories of attention-deficit/hyperactivity disorder (ADHD) suggests that its symptoms arise from a primary deficit in executive functions (EF), defined as neurocognitive processes that maintain an appropriate problem-solving set to attain a later goal. To examine the validity of the EF theory, we conducted a meta-analysis of 83 studies that administered EF measures to groups with ADHD (total N = 3734) and without ADHD (N = 2969). Groups with ADHD exhibited significant impairment on all EF tasks. Effect sizes for all measures fell in the medium range (.46–.69), but the strongest and most consistent effects were obtained on measures of response inhibition, vigilance, working memory, and planning. Weaknesses in EF were significant in both clinic-referred and community samples and were not explained by group differences in intelligence, academic achievement, or symptoms of other disorders. ADHD is associated with significant weaknesses in several key EF domains. However, moderate effect sizes and lack of universality of EF deficits among individuals with ADHD suggest that EF weaknesses are neither necessary nor sufficient to cause all cases of ADHD. Difficulties with EF appear to be one important component of the complex neuropsychology of ADHD.

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      References

        • Aman C.J.
        • Roberts R.J.
        • Pennington B.F.
        A neuropsychological examination of the underlying deficit in attention deficit hyperactivity disorder.
        Dev Psychol. 1998; 34: 956-969
        • August G.J.
        • Garfinkel B.D.
        Behavioral and cognitive subtypes of ADHD.
        J Am Acad Child Adolesc Psychiatry. 1989; 28: 739-748
        • Barceló F.
        Electrophysiological evidence of two different types of error in the Wisconsin Card Sorting Test.
        Neuroreport. 1999; 10: 1299-1303
        • Barkley R.A.
        Behavioral inhibition, sustained attention, and executive function.
        Psychol Bull. 1997; 121: 65-94
        • Barkley R.A.
        • DuPaul G.J.
        • McMurray M.B.
        Comprehensive evaluation of attention deficit disorder with and without hyperactivity as defined by research criteria.
        J Consult Clin Psychol. 1990; 58: 775-789
        • Barkley R.A.
        • Edwards G.
        • Laneri M.
        • Fletcher K.
        • Metevia L.
        Executive functioning, temporal discounting, and sense of time in adolescents with attention deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD).
        J Abnorm Child Psychol. 2001; 29: 541-556
        • Barkley R.A.
        • Grodzinsky G.
        • DuPaul G.J.
        Frontal lobe functions in attention deficit disorder with and without hyperactivity.
        J Abnorm Child Psychol. 1992; 20: 163-188
        • Barnett R.
        • Maruff P.
        • Vance A.
        • Luk E.S.L.
        • Costin J.
        • Wood C.
        • et al.
        Abnormal executive function in attention deficit hyperactivity disorder.
        Psychol Med. 2001; 31: 1107-1115
        • Bedard A.
        • Ickowicz A.
        • Logan G.D.
        • Hogg-Johnson S.
        • Schachar R.
        • Tannock R.
        Selective inhibition in children with attention-deficit hyperactivity disorder off and on stimulant medication.
        J Abnorm Child Psychol. 2003; 31: 315-327
        • Börger N.
        • van der Meere J.
        • Ronner A.
        • Alberts E.
        • Geuze R.
        • Bogte H.
        Heart rate variability and sustained attention in ADHD children.
        J Abnorm Child Psychol. 1999; 20: 163-188
        • Borys S.V.
        • Spitz H.H.
        • Dorans B.A.
        Tower of Hanoi performance of retarded young adults and nonretarded children as a function of solution length and goal state.
        J Exp Child Psychol. 1982; 33: 87-110
        • Boucugnani L.L.
        • Jones R.W.
        Behaviors analogous to frontal lobe dysfunction in children with attention deficit hyperactivity disorder.
        Arch Clin Neuropsychol. 1989; 4: 161-173
        • Brandeis D.
        • van Leeuwen T.H.
        • Rubia K.
        • Vitacco D.
        • Steger J.
        • Pascual-Marqui R.D.
        • et al.
        Neuroelectric mapping reveals precursor of stop failures in children with attention deficits.
        Behav Brain Res. 1998; 94: 111-125
        • Breen M.J.
        Cognitive and behavioral differences in ADHD boys and girls.
        J Child Psychiatry Psychol. 1989; 30: 711-716
        • Brewer V.R.
        • Fletcher J.M.
        • Hiscock M.
        • Davidson K.C.
        Attention processes in children with shunted hydrocephalus versus attention deficit-hyperactivity disorder.
        Neuropsychology. 2001; 15: 185-198
        • Cairney S.
        • Maruff P.
        • Vance A.
        • Barnett R.
        • Luk E.
        • Currie J.
        Contextual abnormalities of saccadic inhibition in children with attention deficit hyperactivity disorder.
        Exp Brain Res. 2001; 141: 507-518
        • Carlin D.
        • Bonerba J.
        • Phipps M.
        • Alexander G.
        • Shapiro M.
        • Grafman J.
        Planning impairments in frontal lobe dementia and frontal lobe lesion patients.
        Neuropsychologia. 2000; 38: 655-665
        • Carte E.T.
        • Nigg J.T.
        • Hinshaw S.P.
        Neuropsychological functioning, motor speed, and language processing in boys with and without ADHD.
        J Abnorm Child Psychol. 1996; 24: 481-498
        • Carter C.S.
        • Krener P.
        • Chaderjian M.
        • Northcutt C.
        • Wolfe V.
        Abnormal processing of irrelevant information in attention deficit hyperactivity disorder.
        Psychiatry Res. 1995; 56: 59-70
      1. Casey BJ (in press): Frontostriatal and frontocerebellar circuitry underlying cognitive control. In: Mayr U, Keele SW, Awh E, editors. Developing Individuality in the Human Brain. Washington, DC: APA Books.

        • Castellanos F.X.
        • Tannock R.
        Neuroscience of attention-deficit/hyperactivity disorder.
        Nat Rev Neurosci. 2002; 3: 617-628
        • Chee P.
        • Logan G.
        • Schachar R.J.
        • Lindsay P.
        • Wachsmuth R.
        Effects of event rate and display time on sustained attention in hyperactive, normal, and control children.
        J Abnorm Child Psychol. 1989; 17: 371-391
        • Chelune G.J.
        • Ferguson W.
        • Koon R.
        • Dickey T.O.
        Frontal lobe disinhibition in attention deficit disorder.
        Child Psychiatry Hum Dev. 1986; 16: 221-234
        • Chhabildas N.
        • Pennington B.F.
        • Willcutt E.G.
        A comparison of the cognitive deficits in the DSM-IV subtypes of ADHD.
        J Abnorm Child Psychol. 2001; 29: 529-540
        • Cohen J.
        Statistical Power Analysis for the Behavioral Sciences. Lawrence Erlbaum Associates, Hillsdale, NJ1988
        • Collings R.D.
        Differences between ADHD inattentive and combined types on the CPT.
        J Psychopathol Behav Assess. 2003; 25: 177-189
        • Cooper H.
        Synthesizing Research. 3rd ed. Sage, Thousand Oaks, CA1998
        • Culbertson W.C.
        • Zillmer E.A.
        The Tower of LondonDX.
        Arch Clin Neuropsychol. 1998; 13: 285-301
        • Delis D.C.
        • Kaplan E.
        • Kramer J.H.
        The Delis-Kaplan Executive Function System. Psychological Corporation, San Antonio, TX2001
        • Demakis G.J.
        A meta-analytic review of the sensitivity of the Wisconsin Card Sorting Test to frontal and lateralized frontal brain damage.
        Neuropsychology. 2003; 17: 255-264
        • Dimoska A.
        • Johnstone S.J.
        • Barry R.J.
        • Clarke A.R.
        Inhibitory motor control in children with attention-deficit/hyperactivity disorder.
        Biol Psychiatry. 2003; 45: 1345-1354
        • Doyle A.E.
        • Willcutt E.G.
        • Seidman L.J.
        • Biederman J.
        • Chouinard V.-A.
        • Silva J.
        • Faraone S.V.
        Attention-deficit/hyperactivity disorder endophenotypes.
        Biol Psychiatry. 2005; 57: 1329-1335
        • Fallgatter A.J.
        • Ehlis A.
        • Seifert J.
        • Strik W.K.
        • Scheuerpflug P.
        • Zillessen K.E.
        • et al.
        Altered response control and anterior cingulate function in attention-deficit/hyperactivity disorder boys.
        Clin Neurophysiol. 2004; 115: 973-981
        • Faraone S.V.
        • Perlis R.H.
        • Doyle A.E.
        • Smoller J.W.
        • Goralnick J.J.
        • Holmgren M.A.
        • Sklar P.
        Molecular genetics of attention-deficit/hyperactivity disorder.
        Biol Psychiatry. 2005; 57: 1313-1323
        • Fischer M.
        • Barkley R.A.
        • Edelbrock C.S.
        • Smallish L.
        The adolescent outcome of hyperactive children diagnosed by research criteria: II. Academic, attentional, and neuropsychological status.
        J Consult Clin Psychol. 1990; 58: 580-588
        • Fuster J.M.
        The Prefrontal Cortex. 2nd ed. Raven, New York1997
        • Garber J.
        • Hollon S.D.
        What can specificity designs say about causality in psychopathology research?.
        Psychol Bull. 1991; 110: 129-136
        • Geurts H.M.
        • Verté S.
        • Oosterlaan J.
        • Roeyers H.
        • Sergeant J.A.
        How specific are executive function deficits in attention deficit hyperactivity disorder and autism?.
        J Child Psychol Psychiatry. 2004; 45: 836-854
        • Gorenstein E.E.
        • Mammato C.A.
        • Sandy J.M.
        Performance of inattentive-overactive children on selected measures of prefrontal-type function.
        J Clin Psychol. 1989; 45: 619-632
        • Grodzinsky G.M.
        • Diamond R.
        Frontal lobe functioning in boys with attention deficit hyperactivity disorder.
        Dev Neuropsychol. 1992; 8: 427-445
        • Heaton R.K.
        Wisconsin Card Sorting Test Manual. Psychological Assessment Resources, Odessa, FL1981
        • Hedges L.V.
        • Olkin I.
        Statistical Methods for Meta-Analysis. Academic Press, Orlando, FL1985
        • Hinshaw S.P.
        • Carte E.T.
        • Sami N.
        • Treuting J.J.
        • Zupan B.A.
        Preadolescent girls with attention-deficit/hyperactivity disorder: II. Neuropsychological performance in relation to subtypes and individual classification.
        J Consult Clin Psychol. 2002; 70: 1099-1111
        • Homack S.
        • Riccio C.A.
        A meta-analysis of the sensitivity and specificity of the Stroop Color and Word Test with children.
        Arch Clin Neuropsychol. 2004; 19: 725-743
        • Hooks K.
        • Milich R.
        • Lorch E.P.
        Sustained and selective attention in boys with attention deficit hyperactivity disorder.
        J Clin Child Psychol. 1994; 23: 69-77
        • Horn W.F.
        • Wagner A.E.
        • Ialongo N.
        Sex differences in school-aged children with pervasive attention deficit hyperactivity disorder.
        J Abnorm Child Psychol. 1989; 17: 109-125
        • Houghton S.
        • Douglas G.
        • West J.
        • Whiting K.
        • Wall M.
        • Langsford S.
        • Powell L.
        • et al.
        Differential patterns of executive function in children with attention-deficit hyperactivity disorder according to gender and subtype.
        J Child Neurol. 1999; 14: 801-805
        • Huang-Pollock C.L.
        • Nigg J.T.
        Searching for the attention deficit in attention deficit hyperactivity disorder.
        Clin Psychol Rev. 2003; 23: 801-830
        • Jennings R.J.
        • van der Molen M.W.
        • Pelham W.
        • Debski K.B.
        • Hoza B.
        Inhibition in boys with Attention Deficit Hyperactivity Disorder as indexed by heart rate change.
        Dev Psychol. 1997; 33: 308-318
        • Karatekin C.
        • Asarnow R.F.
        Working memory in childhood-onset schizophrenia and attention deficit/hyperactivity disorder.
        Psychiatry Res. 1998; 80: 165-176
        • Kempton S.
        • Vance A.
        • Maruff P.
        • Luk E.
        • Costin J.
        • Pantelis C.
        Executive function and attention deficit hyperactivity disorder.
        Psychol Med. 1999; 29: 527-538
        • Klorman R.
        • Hazel-Fernandez L.A.
        • Shaywitz S.E.
        • Fletcher J.M.
        • Marchione K.E.
        • Holahan J.M.
        • et al.
        Executive functioning deficits in attention-deficit/hyperactivity disorder are independent of oppositional defiant or reading disorder.
        J Am Acad Child Adolesc Psychiatry. 1999; 27: 163-170
        • Konrad K.
        • Gauggel S.
        • Manz A.
        • Schöll M.
        Lack of inhibition.
        Child Neuropsychol. 2000; 6: 286-296
        • Kubler A.
        • Murphy K.
        • Kaufman J.
        • Stein E.A.
        • Garavan H.
        Co-ordination within and between verbal and visuospatial working memory.
        Neuroimage. 2003; 20: 1298-1308
        • Kuntsi J.
        • Oosterlaan J.
        • Stevenson J.
        Psychological mechanisms in hyperactivity: I. Response inhibition deficit, working memory impairment, delay aversion, or something else?.
        J Child Psychol Psychiatry. 2001; 42: 199-210
        • Kuntsi J.
        • Stevenson J.
        • Oosterlaan J.
        • Sonuga-Barke E.J.S.
        Test-retest reliability of a new delay aversion task and executive function measures.
        Br J Dev Psychol. 2001; 19: 339-348
        • Lahey B.B.
        • Pelham W.E.
        • Stein M.A.
        • Loney J.
        • Trapani C.
        • Nugent K.
        • et al.
        Validity of DSM-IV attention-deficit/hyperactivity disorder for younger children.
        J Am Acad Child Adolesc Psychiatry. 1998; 37: 695-702
        • Levin H.S.
        • Song J.
        • Ewing-Cobbs L.
        • Roberson G.
        Porteus maze performance following traumatic brain injury in children.
        Neuropsychology. 2001; 15: 557-567
        • Logan G.D.
        • Schachar R.J.
        • Tannock R.
        Impulsivity and inhibitory control.
        Psychol Sci. 1997; 8: 60-64
        • Loge D.
        • Staton D.
        • Beatty W.
        Performance of children with ADHD on tests of frontal lobe dysfunction.
        J Am Acad Child Adolesc Psychiatry. 1990; 29: 540-545
        • Manassis K.
        • Tannock R.
        • Barbosa J.
        Dichotic listening and response inhibition in children with comorbid anxiety disorders and ADHD.
        J Am Acad Child Adolesc Psychiatry. 2000; 39: 1152-1159
        • Mariani M.A.
        • Barkley R.A.
        Neuropsychological and academic functioning in preschool boys with attention deficit hyperactivity disorder.
        Dev Neuropsychol. 1997; 13: 111-129
        • Mataró M.
        • Garcia-Sánchez C.
        • Junqué C.
        • Estévez-González A.
        • Pujol J.
        Magnetic resonance imaging measurement of the caudate nucleus in adolescents with attention-deficit hyperactivity disorder and its relationship with neuropsychological and behavioral measures.
        Arch Neurol. 1997; 54: 963-967
        • McGee R.
        • Williams S.
        • Moffitt T.
        • Anderson J.
        A comparison of 13-year-old boys with attention deficit and/or reading disorder on neuropsychological measures.
        J Abnorm Child Psychol. 1989; 17: 37-53
        • McInnes A.
        • Humphries T.
        • Hogg-Johnson S.
        • Tannock R.
        Listening comprehension and working memory are impaired in attention-deficit/hyperactivity disorder irrespective of language impairment.
        J Abnorm Child Psychol. 2003; 31: 427-443
        • Mentzel H.J.
        • Gaser C.
        • Volz H.P.
        • Rzanny R.
        • Hager F.
        • Sauer H.
        • et al.
        Cognitive stimulation with the Wisconsin Card Sorting Test.
        Radiology. 1998; 207: 399-404
        • Middleton F.A.
        • Strick P.L.
        Cerebellar projections to the prefrontal cortex of the primate.
        J Neurosci. 2001; 2: 700-712
        • Middleton F.A.
        • Strick P.L.
        Basal-ganglia “projections” to the prefrontal cortex of the primate.
        Cereb Cortex. 2002; 9: 926-935
        • Miyake A.
        • Friedman N.P.
        • Emerson M.J.
        • Witzki A.H.
        • Howerter A.
        The unity and diversity of executive functions and their contributions to complex frontal lobe tasks.
        Cog Psychol. 2000; 41: 49-100
        • Newcorn J.H.
        • Halperin J.M.
        • Healey J.M.
        • O’Brien J.D.
        • Pascualvaca D.M.
        • Wolf L.E.
        • et al.
        Are ADDH and ADHD the same or different?.
        J Am Acad Child Adolesc Psychiatry. 1989; 285: 734-738
        • Nigg J.T.
        The ADHD response inhibition deficit as measured by the Stop Task.
        J Abnorm Child Psychol. 1999; 27: 391-400
        • Nigg J.T.
        Is ADHD a disinhibitory disorder?.
        Psychol Bull. 2001; 127: 571-598
        • Nigg J.T.
        • Blaskey L.G.
        • Huang-Pollock C.L.
        • Rappley M.D.
        Neuropsychological executive functions and DSM-IV ADHD subtypes.
        J Am Acad Child Adolesc Psychiatry. 2002; 41: 59-66
        • Nigg J.T.
        • Blaskey L.
        • Stawicki J.
        • Sachek J.
        Evaluating the endophenotype model of ADHD neuropsychological deficit.
        J Abnorm Psychol. 2004; 113: 614-625
        • Nigg J.T.
        • Goldsmith H.H.
        • Sachek J.
        Temperament and attention-deficit/hyperactivity disorder.
        J Clin Child Adol Psychol. 2004; 33: 42-53
        • Nigg J.T.
        • Hinshaw S.P.
        • Carte E.
        • Treuting J.
        Neuropsychological correlates of childhood attention-deficit/hyperactivity disorder.
        J Abnorm Psychol. 1998; 107: 468-480
      2. Nigg JT, Stavro G, Ettenhofer M, Hambrick D, Miller T, Henderson JM (in press): Executive functions and ADHD in adults: Evidence for selective effects on ADHD symptom domains. J Abnorm Psychol.

        • Nigg J.T.
        • Willcutt E.G.
        • Doyle A.E.
        • Sonuga-Barke E.J.S.
        Causal heterogeneity in attention-deficit/hyperactivity disorder.
        Biol Psychiatry. 2005; 57: 1224-1230
        • Oie M.
        • Sundet K.
        • Rund B.R.
        Contrasts in memory functions between adolescents with schizophrenia or ADHD.
        Neuropsychologia. 1999; 37: 1351-1358
        • Oosterlaan J.
        • Sergeant J.A.
        Effects of reward and response cost on response inhibition in AD/HD, disruptive, anxious, and normal children.
        J Abnorm Child Psychol. 1998; 26: 161-174
        • Oosterlaan J.
        • Sergeant J.A.
        Inhibition in ADHD, aggressive, and anxious children.
        J Abnorm Child Psychol. 1996; 24: 19-36
        • Overtoom C.C.E.
        • Kenemans J.L.
        • Verbaten M.N.
        • Kemner C.
        • van der Molen M.W.
        • van Engeland H.
        • et al.
        Inhibition in children with attention-deficit/hyperactivity disorder.
        Biol Psychiatry. 2002; 51: 668-676
        • Owen A.M.
        • Doyon J.
        • Petrides M.
        • Evans A.C.
        Planning and spatial working memory.
        Eur J Neurosci. 1996; 8: 353-364
        • Owen A.M.
        • Morris R.G.
        • Sahakian B.J.
        • Polkey C.E.
        • Robbins T.W.
        Double dissociations of memory and executive functions in working memory task following frontal lobe excision, temporal lobe excisions or amygdalo-hippocampectomy in man.
        Brain. 1996; 119: 1597-1615
        • Ozonoff S.
        • Jensen J.
        Brief report.
        J Aut Dev Disord. 1999; 29: 171-177
        • Pennington B.F.
        The Development of Psychopathology. Guilford Press, New York2002
        • Pennington B.F.
        Toward a new neuropsychological model of attention-deficit/hyperactivity disorder.
        Biol Psychiatry. 2005; 57: 1221-1223
        • Pennington B.F.
        • Groisser D.
        • Welsh M.C.
        Contrasting cognitive deficits in attention deficit hyperactivity disorder versus reading disability.
        Dev Psychol. 1993; 29: 511-523
        • Pennington B.F.
        • Ozonoff S.
        Executive functions and developmental psychopathology.
        J Child Psychol Psychiatry. 1996; 37: 51-87
        • Petrides M.
        • Milner B.
        Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man.
        Neuropsychologia. 1982; 20: 249-262
        • Pineda D.
        • Ardila A.
        • Rosselli M.
        Neuropsychological and behavioural assessment of ADHD in seven- and 12-year-old children.
        J Learn Disabil. 1999; 32: 159-173
        • Pliszka S.R.
        Comorbidity of attention deficit hyperactivity disorder and overanxious disorder.
        J Am Acad Child Adolesc Psychiatry. 1992; 31: 197-209
        • Pliszka S.R.
        • Borcherding S.H.
        • Spratley K.
        • Leon S.
        • Irick S.
        Measuring inhibitory control in children.
        J Dev Behav Ped. 1997; 18: 254-259
        • Pliszka S.R.
        • Liotti M.
        • Woldorff M.G.
        Inhibitory control in children with attention-deficit/hyperactivity disorder.
        Biol Psychiatry. 2000; 48: 238-246
        • Porteus S.D.
        Porteus Maze Test. Psychological Corporation, New York1965
        • Purvis K.
        • Tannock R.T.
        Phonological processing, not inhibitory control, differentiates ADHD and reading disorder.
        J Am Acad Child Adolesc Psychiatry. 2000; 39: 485-494
        • Reeve W.V.
        • Schandler S.L.
        Frontal lobe functioning in adolescents with attention deficit hyperactivity disorder.
        Adolesc. 2001; 36: 749-765
        • Reitan R.
        • Wolfson D.
        The Halstead-Reitan Neuropsychological Test Battery. Neuropsychology Press, Tucson, AZ1985
        • Robbins T.W.
        • James M.
        • Owen A.M.
        • Sahakian B.J.
        • Lawrence A.D.
        • McInnes L.
        • et al.
        A study of performance on tests from the CANTAB battery sensitive to frontal lobe dysfunction in a large sample of normal volunteers.
        J Intern Neuropsych Soc. 1998; 4: 474-480
        • Rowe J.B.
        • Owen A.M.
        • Johnsrude I.S.
        • Passingham R.E.
        Imaging the mental components of a planning task.
        Neuropsychologia. 2001; 39: 315-327
        • Rubia K.
        • Oosterlaan J.
        • Sergeant J.A.
        • Brandeis D.
        • Leeuwen T.V.
        Inhibitory dysfunction in hyperactive boys.
        Behav Brain Res. 1998; 94: 25-32
        • Rubia K.
        • Overmeyer S.
        • Taylor E.
        • Brammer M.
        • Williams S.C.
        • Simmons A.
        • et al.
        Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control.
        Am J Psychiatry. 1999; 156: 891-896
        • Rubia K.
        • Taylor E.
        • Smith A.B.
        • Oksannen H.
        • Overmeyer S.
        • Newman S.
        Neuropsychological analyses of impulsiveness in childhood hyperactivity.
        Br J Psychiatry. 2001; 179: 138-143
        • Rucklidge J.J.
        • Tannock R.
        Neuropsychological profiles of adolescents with ADHD.
        J Child Psychol Psychiatry. 2002; 43: 988-1003
        • Rund B.R.
        • Zeiner P.
        • Sundet K.
        • Oie M.
        • Bryhn G.
        No vigilance deficit found in either young schizophrenic or ADHD subjects.
        Scand J Psychol. 1998; 39: 101-107
        • Sagvolden T.
        • Russell V.A.
        • Aase H.
        • Johansen E.B.
        • Farshbaf M.
        Rodent models of attention-deficit/hyperactivity disorder.
        Biol Psychiatry. 2005; 57: 1239-1247
        • Sartory G.
        • Heine A.
        • Müller B.W.
        • Elvermann-Hallner A.
        Event- and motor-related potentials during the continuous performance task in attention-deficit/hyperactivity disorder.
        J Psychophys. 2002; 16: 97-106
        • Sawyer A.M.
        • Taylor E.
        • Chadwick O.
        The effect of off-task behaviors on the task performance of hyperkinetic children.
        J Atten Dis. 2001; 5: 1-10
        • Schachar R.
        • Logan G.
        Are hyperactive children deficient in attentional capacity?.
        J Abnorm Child Psychol. 1990; 18: 493-513
        • Schachar R.
        • Logan G.
        • Wachsmuth R.
        • Chajczyk D.
        Attaining and maintaining preparation.
        J Abnorm Child Psychol. 1988; 16: 361-378
        • Schachar R.
        • Mota V.L.
        • Logan G.D.
        • Tannock R.
        • Klim P.
        Confirmation of an inhibitory control deficit in attention-deficit/hyperactivity disorder.
        J Abnorm Child Psychol. 2000; 28: 227-235
        • Schachar R.
        • Tannock R.
        Test of four hypotheses for the comorbidity of attention deficit hyperactivity disorder and conduct disorder.
        J Am Acad Child Adolesc Psychiatry. 1995; 34: 639-648
        • Schachar R.J.
        • Tannock R.
        • Marriott M.
        • Logan G.
        Control of response processes in attention deficit hyperactivity disorder.
        J Abnorm Child Psychol. 1995; 23: 411-437
        • Scheres A.
        • Oosterlaan J.
        • Sergeant J.A.
        Response execution and inhibition in children with AD/HD and other disruptive disorders.
        J Child Psychol Psychiatry. 2001; 42: 347-357
        • Schmitz M.
        • Cadore L.
        • Paczko M.
        • Kipper L.
        • Chaves M.
        • Rohde L.A.
        • et al.
        Neuropsychological performance in DSM-IV ADHD subtypes.
        Can J Psychiatry. 2002; 47: 863-869
        • Seidman L.J.
        • Biederman J.
        • Faraone S.V.
        • Weber W.
        • Mennin D.
        • Jones J.
        A pilot study of neuropsychological functioning in girls with ADHD.
        J Am Acad Child Adolesc Psychiatry. 1997; 36: 366-373
        • Seidman L.J.
        • Biederman J.
        • Faraone S.V.
        • Weber W.
        • Ouellette C.
        Toward defining a neuropsychology of attention deficit hyperactivity disorder.
        J Cons Clin Psychol. 1997; 65: 150-160
        • Semrud-Clikeman M.
        • Steingard R.J.
        • Filipek P.
        • Biederman J.
        • Bekken K.
        • Renshaw P.
        Using MRI to examine brain-behavior relationships in males with attention deficit hyperactivity disorder.
        J Am Acad Child Adolesc Psychiatry. 2000; 39: 477-484
        • Sergeant J.A.
        Modeling attention-deficit/hyperactivity disorder.
        Biol Psychiatry. 2005; 57: 1248-1255
        • Sergeant J.A.
        • Geurts H.
        • Huijbregts S.
        • Scheres A.
        • Oosterlaan J.
        The top and bottom of ADHD.
        Neurosci Biobehav Rev. 2003; 27: 583-592
        • Sergeant J.A.
        • Guerts H.
        • Oosterlaan J.
        How specific is a deficit of executive functioning for attention-deficit/hyperactivity disorder?.
        Behav Brain Res. 2002; 130: 3-28
        • Shallice T.
        Specific impairments of planning.
        Phil Trans Roy Soc London. 1982; 298: 199-209
        • Shue K.
        • Douglas V.I.
        Attention deficit hyperactivity disorder and the frontal lobe syndrome.
        Brain Cog. 1992; 20: 104-124
        • Siegel L.S.
        • Ryan E.B.
        The development of working memory in normally achieving and subtypes of learning disabled children.
        Child Dev. 1989; 60: 973-980
        • Solanto M.V.
        • Abikoff H.
        • Sonuga-Barke E.
        • Schachar R.
        • Logan G.D.
        • Wigal T.
        • et al.
        The ecological validity of delay aversion and response inhibition as measures of impulsivity in AD/HD.
        J Abnorm Child Psychol. 2001; 29: 215-228
        • Sonuga-Barke E.J.S.
        The dual pathway model of ADHD.
        Neurosci Biobehav Rev. 2003; 27: 593-604
        • Sonuga-Barke E.J.S.
        Causal models of attention-deficit/hyperactivity disorder.
        Biol Psychiatry. 2005; 57: 1231-1238
        • Stevens J.
        • Quittner A.L.
        • Zuckerman J.B.
        • Moore S.
        Behavioral inhibition, self-regulation of motivation, and working memory in children with attention deficit hyperactivity disorder.
        Dev Neuropsychol. 2002; 21: 117-139
        • Stuss D.T.
        • Benson D.F.
        The Frontal Lobes. Raven Press, New York1986
        • Toplak M.E.
        • Rucklidge J.J.
        • Hetherington R.
        • John S.C.F.
        • Tannock R.
        Time perception deficits in attention-deficit/hyperactivity disorder and comorbid reading difficulties in child and adolescent samples.
        J Child Psychol Psychiatry. 2003; 44: 888-903
        • Tripp G.
        • Luk S.L.
        • Schaughency E.A.
        • Singh R.
        DSM-IV and ICD-10.
        J Am Acad Child Adolesc Psychiatry. 1999; 38: 156-164
        • Tripp G.
        • Ryan J.
        • Peace K.
        Neuropsychological functioning in children with DSM-IV combined type attention deficit hyperactivity disorder.
        Aust N Z J Psychiatry. 2002; 36: 771-779
        • Vaidya C.J.
        • Austin G.
        • Kirkorian G.
        • Ridlehuber H.W.
        • Desmond J.E.
        • Glover G.H.
        • Gabrieli J.D.
        Selective effects of methylphenidate in attention deficit hyperactivity disorder.
        Proc Nat Acad Sci U S A. 1998; 95: 14494-14499
        • van Leeuwen T.H.
        • Steinhausen H.C.
        • Overtoom C.C.
        • Pascual-Marqui R.D.
        • van’t Klooster B.
        • Rothenberger A.
        • et al.
        The continuous performance test revisited with neuroelectric mapping.
        Behav Brain Res. 1998; 94: 97-110
        • Van Mourik R.
        • Oosterlaan J.
        • Sergeant J.A.
        The Stroop revisited.
        J Child Psychol Psychiatry. 2005; 46: 150-185
        • Waber D.P.
        • Holmes J.M.
        Assessing children’s copy productions of the Rey-Osterreith Complex Figure.
        J Clin Exp Neuropsychol. 1985; 7: 264-280
        • Wager T.D.
        • Smith E.E.
        Neuroimaging studies of working memory.
        Cogn Affect Behav Neurosci. 2003; 3: 255-274
        • Wechsler D.
        Manual for the Wechsler Intelligence Scale for Children. 3rd ed. Psychological Corporation, San Antonio, TX1991
        • Welsh M.C.
        • Pennington B.F.
        Assessing frontal lobe functioning in children.
        Dev Neuropsychol. 1988; 4: 199-230
        • Weyandt L.L.
        • Willis W.G.
        Executive functions in school-aged children.
        Dev Neuropsychol. 1994; 10: 1697-1713
        • Wiers R.W.
        • Gunning W.B.
        • Sergeant J.A.
        Is a mild deficit in executive functions in boys related to childhood ADHD or to multigenerational alcoholism?.
        J Abnorm Child Psychol. 1998; 26: 415-430
        • Willcutt E.G.
        • Brodsky K.
        • Chhabildas N.
        • Shanahan M.
        • Yerys B.
        • Scott A.
        • Pennington B.F.
        The neuropsychology of ADHD.
        in: Gozal D. Molfese D.L. Attention Deficit Hyperactivity Disorder From Genes to Patients. Humana Press, Totowa, NJ2005: 185-213
        • Willcutt E.G.
        • Pennington B.F.
        • Boada R.
        • Tunick R.A.
        • Ogline J.
        • Chhabildas N.A.
        • Olson R.K.
        A comparison of the cognitive deficits in reading disability and attention-deficit/hyperactivity disorder.
        J Abnorm Psychol. 2001; 110: 157-172
        • Willcutt E.G.
        • Pennington B.F.
        • Chhabildas N.A.
        • Olson R.K.
        • Hulslander J.L.
        Neuropsychological analyses of comorbidity between RD and ADHD.
        Dev Neuropsychol. 2005; 27: 35-78
        • Williams D.
        • Stott C.M.
        • Goodyer I.M.
        • Sahakian B.J.
        Specific language impairment with or without hyperactivity.
        Dev Med Child Neurol. 2000; 42: 368-375
        • Wu K.K.
        • Anderson V.
        • Castiello U.
        Neuropsychological evaluation of deficits in executive functioning for ADHD children with or without learning disabilities.
        Dev Neuropsychol. 2002; 22: 501-531
        • Yeo R.A.
        • Hill D.E.
        • Campbell R.A.
        • Vigil J.
        • Petropoulos H.
        • Hart B.
        • et al.
        Proton magnetic resonance spectroscopy investigation of the right frontal lobe in children with attention-deficit/hyperactivity disorder.
        J Am Acad Child Adolesc Psychiatry. 2003; 42: 303-310