Advertisement
Brief report| Volume 40, ISSUE 8, P811-813, October 15, 1996

Lower frequency of apolipoprotein E4 allele in an “elderly” Down's syndrome population

      This paper is only available as a PDF. To read, Please Download here.

      Key Words

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • American Psychiatric Association
        4th ed. Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Press, New York1994
        • Avramopoulos D
        • Mikkelsen M
        • Vassilopoulos D
        • Grigoriadou M
        • Peterson M
        Apolipoprotein E allele distribution in parents of Down's syndrome children.
        Lancet. 1996; 347: 862-865
        • Berg JM
        Down syndrome.
        in: Berg JM Karlinsky H Holland AJ Alzheimer Disease, Down Syndrome and Their Relationship. Oxford Medical Publications, Washington, DC1993: 19-34
        • Crook R
        • Hardy J
        • Duff K
        Single-day apolipoprotein E genotyping.
        J Neurosci Methods. 1994; 53: 125-127
        • Gerdes L
        • Klausen I
        • Sihm I
        • Faergeman O
        Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world.
        Genet Epidemiol. 1992; 9: 155-167
        • Hardy J
        • Houlden H
        • Collinge J
        • et al.
        Apolipoprotein E genotypes and Alzheimer's disease.
        Lancet. 1993; 342: 737-738
        • Hardy J
        • Crook R
        • Perry R
        • Raghavan R
        • Roberts G
        ApoE genotype and Down's syndrome.
        Lancet. 1994; 343: 979-980
        • Heston LL
        Alzheimer's disease and Down's syndrome: New insights.
        Am J Psychiatry. 1985; 103: 566-578
        • Jervis GA
        Early senile dementia in mongoloid idiocy.
        Am J Psychiatry. 1948; 105: 102-106
        • Lai F
        • Williams RS
        A prospective study of Alzheimer disease in Down syndrome.
        Arch Neurol. 1989; 46: 849-853
        • Poirier J
        • Davignon J
        • Bouthillier D
        • Kogan S
        • Bertrand P
        • Gauthiers S
        Apolipoprotein E polymorphism and Alzheimer's disease.
        Lancet. 1993; 342: 697-699
        • Prasher V
        • Krishnan VHR
        Age of onset and duration of dementia in people with Down's syndrome: Integration of 98 reported cases in the literature.
        Int J Geriatr Psychiatry. 1993; 8: 915-922
        • Royston M
        • Mann D
        • Pickering-Brown S
        • et al.
        Apolipoprotein E e2 allele promotes longevity and protects patients with Down's syndrome from dementia.
        Neuroreports. 1994; 5: 1
        • Rumble M
        • Retallack R
        • Hilbich C
        • et al.
        Amyloid A4 protein and its precursors in Down's syndrome and Alzheimer's disease.
        N Engl J Med. 1993; 320: 1446-1552
        • Saunders A
        • Schmader K
        • Breitner J
        • et al.
        Apolipoprotein E e4 allele distributions in late onset Alzheimer's disease and in other amyloid forming diseases.
        Lancet. 1993; 342: 710-711
        • Schachter F
        • Delanef-Faire L
        • Guenot F
        • et al.
        Genetic associations with human longevity at the ApoE and ACE loci.
        Nat Genet. 1994; 6: 29-32
        • Strittmatter WJ
        • Saunders AM
        • Schmechel D
        • Pericak-Vance M
        • Roses A
        Apolipoprotein E: High avidity binding to beta-amyloid and increased frequency of type 4 allele in late onset familial Alzheimer's disease.
        in: Proc Natl Acad Sci USA. 90. 1993: 1977-1981
        • van Duijn C
        • de Knijff P
        • Cruts M
        • et al.
        Apolipoprotein E4 in a population-based study of early onset Alzheimer's disease.
        Nat Genet. 1994; 1994: 74-78
        • Wisniewski KE
        • Wisniewski HM
        • Wen GY
        Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome.
        Ann Neurol. 1985; 17: 278-282
        • Wisniewski T
        • Morelli M
        • Wegiel J
        • Levy E
        • Wisniewski HM
        • Frangione B
        The influence of apolipoprotein E isotypes on Alzheimer's disease pathology in 40 cases of Down's syndrome.
        Ann Neurol. 1995; 37: 136-138