Brief report| Volume 40, ISSUE 6, P550-552, September 15, 1996

Effect of CI-988, a cholecystokinin-B receptor antagonist, on lactate-induced panic

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        • Bammert Adams J
        • Pyke RE
        • Costa J
        • et al.
        A double-blind, placebo-controlled study of a CCK-B receptor antagonist, CI-988, in patients with generalized anxiety disorder.
        J Clin Psychopharmacol. 1995; 15: 428-434
        • Bradwejn J
        • Koszycki D
        • Shriqui C
        Enhanced sensitivity to cholecystokinin-tetrapeptide in panic disorder: Clinical and behavioral findings.
        Arch Gen Psychiatry. 1991; 48: 603-610
        • Bradwejn J
        • Koszycki D
        • Couetoux du Tetre A
        • et al.
        The panicogenic effects of cholecystokinin tetrapeptide are antagonized by L-365,260, a central cholecystokinin receptor antagonist, in patients with panic disorder.
        Arch Gen Psychiatry. 1994; 51: 486-493
        • Bradwejn J
        • Paradis M
        • Koszycki D
        • Reece P
        • Sedman A
        The effects of CI-988 on CCK-4-panic in healthy volunteers.
        in: Presented at the annual meeting of the ACNP. 1994
        • Cowley D
        • Arana G
        The diagnostic utility of lactate sensitivity in panic disorder.
        Arch Gen Psychiatry. 1990; 47: 277-284
        • Powell KR
        • Barrett JE
        Evaluation of the effects of PD 134308 (CI-988), a CCK-B antagonist, on the punished responding of squirrel monkeys.
        Neuropeptides. 1991; 19 (suppl): 75-78
        • Singh L
        • Field M
        • Hughes J
        • et al.
        The behavioural properties of CI-988, a selective cholecystokinin B receptor antagonist.
        Br J Pharmacol. 1991; 104: 239-245
        • Singh L
        • Lewis A
        • Field M
        • Hughes J
        • Woodruff G
        Evidence for an involvement of the brain cholecystokinin B receptor in anxiety.
        in: Proc Natl Acad Sci USA. 88. 1991: 1130-1133
        • Van der Molen GM
        • van den Hout MA
        • Vroeman J
        • Lousberg H
        • Griez E
        Cognitive factors in lactate-induced anxiety.
        Behav Res Ther. 1986; 24: 677-680
        • Westenberg H
        • van Megen HGM
        • den Boer JA
        Effect of the cholecystokinin-B receptor antagonist L-365,260 on lactate-induced panic in panic disorder (PD) patients.
        Psychopharmacol Bull. 1994; 30: 644