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We have developed a unique computer model of the CA3 region of the hippocampus that
simulates the P50 auditory evoked potential response to repeated stimuli in order
to study the neuronal circuits involved in a sensory processing deficit associated
with schizophrenia. Our computer model of the CA3 hippocampal network includes recurrent
activation from within the CA3 region as well as input from the entorhinal cortex
and the medial septal nucleus. We used the model to help us determine if the cortical
and septal inputs to the CA3 hippocampus alone are responsible for the gating of auditory
evoked activity, or if the strong recurrent activity within the CA3 region contributes
to this phenomenon. The model suggests that the medial septal input is critical for
normal gating; however, to a large extent the activity of the medial septal input
can be replaced by simulated stimulation of the hippocampal neurons by a nicotinic
agonist. The model is thus consistent with experimental data that show that nicotine
restores gating of the N40 evoked potential in fimbria-fornix lesioned rats and of
the P50 evoked potential in schizophrenic patients.
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Article info
Publication history
Received in revised form:
November 24,
1995
Received:
June 1,
1994
Identification
Copyright
© 1996 Society of Biological Psychiatry. Published by Elsevier Inc.
