The relationship of information-processing deficits and clinical symptoms in schizotypal personality disorder

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      Individuals with schizotypal personality disorder (SPD) are thought to be phenotypically related to individuals with schizophrenia. This assumption is partially supported by the fact that SPD patients have deficits on biological markers similar to those found in schizophrenia. Visual backward masking (VBM) performance and critical stimulus duration (CSD), measures of information processing found to be abnormal in schizophrenia patients, were assessed in 14 SPD and 21 comparison subjects. There was no significant difference between groups in VBM performance; however; there were significant correlations between VBM deficits and the number of SPD symptoms, as well as elevated scores on the Ego Impairment Index (EII). Additionally, there was a trend (p = .056) toward elevations in CSD in the SPD versus the comparison group and CSD inflation appears to be most prominent in individuals with a greater number of social deficit symptoms and elevated physical anhedonia scores. These findings suggest an important relationship between symptoms of SPD and neurophysiologic deficits.

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        • Arndt S
        • Alliger RJ
        • Andreasen NC
        The distinction of positive and negative symptoms: The failure of a twodimensional model.
        Br J Psychiatry. 1991; 158: 317-322
        • Bilder RM
        • Mukherjee S
        • Rieder RO
        • Pandurangi AK
        Symptomatic and neuropsychological components of defect states.
        Schizophr Bull. 1985; 11: 409-419
        • Braff DL
        Impaired speed of information processing in non-medicated schizotypal patients.
        Schizophr Bull. 1981; 7: 499-508
        • Braff DL
        Sensory input deficits and negative symptoms in schizophrenic patients.
        Am J Psychiatry. 1989; 146: 1006-1011
        • Braff DL
        Information processing and attention in schizophrenia.
        Schizophr Bull. 1993; 19: 233-259
        • Braff DL
        • Saccuzzo DP
        Information processing dysfunction in paranoid schizophrenia: A two factor deficit.
        Am J Psychiatry. 1981; 138: 1051-1056
        • Braff DL
        • Saccuzzo DP
        • Geyer MA
        Information processing dysfunction in schizophrenia: Studies of visual backward masking, sensorimotor gating and habituation.
        in: Zubin J Steinhauer S Gruzelier JH Handbook of Schizophrenia, Volume 4. Neuropsychology, Psychophysiology, and Information Processing. Elsevier, Greenwich CT1991: 303-334
        • Braff DL
        • Grillon C
        • Geyer MA
        Gating and habituation of the startle reflex in schizophrenic patients.
        Arch Gen Psychiatry. 1992; 49: 206-215
        • Butler RW
        • Braff DL
        Delusions: A review and integration.
        Schizophr Bull. 1991; 17: 633-647
        • Butler RW
        • Jenkins MA
        • Braff DL
        On the abnormality of normal comparison groups: The identification of psychosisproneness and substance abuse in putatively normal research subjects.
        Am J Psychiatry. 1993; 150: 1386-1391
        • Cadenhead KS
        • Geyer MA
        • Braff DL
        Impaired startle prepulse inhibition and habituation in schizotypal personality disordered patients.
        Am J Psychiatry. 1993; 150: 1862-1867
      1. Cadenhead KS, Kumar C, Braff DL (in press): Clinical and experimental characteristics of “hypothetically psychosisprone” college students. Psychiatry Res.

        • Chapman LJ
        • Chapman JP
        The search for symptoms predictive of schizophrenia.
        Schizophr Bull. 1987; 13: 5497-5503
        • Exner JE
        2nd ed. The Rorschach: A Comprehensive System. vol 2. Wiley, Amsterdam1991
        • Frith CD
        Consciousness, information processing and schizophrenia.
        Br J Psychiatry. 1979; 134: 225-235
        • Frith CD
        Schizophrenia: An abnormality of consciousness?.
        in: Underwood G. Stevens P. Aspects of Consciousness. 2nd ed. Academic Press, New York1981
        • Green M
        • Walker E
        Susceptibility to backward masking in schizophrenic patients with positive versus negative symptoms.
        Am J Psychology. 1984; 141: 1273
        • Green MF
        • Nuechterlein KH
        • Mintz J
        Backward masking in schizophrenia and mania: I. Specifying a mechanism.
        Arch Gen Psychiatry. 1994; 51: 939-944
        • Green MF
        • Nuechterlein KH
        • Mintz J
        Backward masking in schizophrenia and mania: II. Specifying the visual channels.
        Arch Gen Psychiatry. 1994; 51: 945-951
        • Gunderson J
        • Singer M
        Defining borderline patients: An overview.
        Am J Psychiatry. 1975; 132: 1
        • Gunderson JG
        • Siever LJ
        • Spaulding E
        The search for a schizotype: Crossing the border again.
        Arch Gen Psychiatry. 1983; 40: 15-22
        • Kendler KS
        • Gruenberg AM
        • Kinney DK
        Independent diagnoses of adoptees and relatives as defined by DSM-III in the provincial and national samples of the Danish adoption study of schizophrenia.
        Arch Gen Psychiatry. 1994; 51: 456-468
        • Kety SS
        • Wender PH
        • Jacobsen LJ
        • et al.
        Mental illness in the biological and adoptive relatives of schizophrenic adoptees: Replication of the Copenhagen study in the rest of Denmark.
        Arch Gen Psychiatry. 1994; 51: 442-455
        • Lyons M
        • Meria M
        • Young L
        • Kreman WS
        Impaired neuropsychological functioning in symptomatic volunteers with schizotypy: Preliminary findings.
        Biol Psychiatry. 1991; 30: 424-426
        • Merritt RD
        • Balogh DW
        Backward masking spatial frequency effects among hypothetically schizotypal individuals.
        Schizophr Bull. 1989; 15: 573-583
        • McGhie A
        • Chapman J
        Disorders of attention and perception in early schizophrenia.
        Br J Med Psycology. 1961; 34: 103-116
        • Perry W
        • Braff DL
        Information-processing deficits and thought disorder in schizophrenia.
        Am J Psychiatry. 1994; 151: 363-367
        • Perry W
        • Viglione DJ
        The Ego Impairment Index as a predictor of outcome in melancholic depressed patients treated with tricyclic antidepressants.
        J Personality Assessment. 1991; 56: 487-501
        • Perry W
        • Viglione DJ
        • Braff DL
        The ego impairment index and schizophrenia: A validation study.
        J Personality Assessment. 1992; 59: 165-175
        • Perry W
        • Moore D
        • Braff D
        Gender differences on thought disturbance measures among schizophrenic patients.
        Am J Psychiatry. 1995; 152: 1298-1301
        • Perry W
        • McDougall A
        • Viglione DJ
        The Ego Impairment Index: A five year follow-up study.
        J Personality Assessment. 1995; 64: 112-118
        • Raine A
        • Reynolds C
        • Lencz T
        • Scerbo A
        • Triphon N
        • Kim D
        Cognitive-perceptual, interpersonal and disorganized features of schizotypal personality.
        Schizophr Bull. 1994; 20: 191-201
        • Rotter M
        • Kalus O
        • Losonczy M
        • et al.
        Lateral ventricle enlargement in schizotypal personality disorder.
        Biol Psychiatry. 1991; 29: 287A
        • Saccuzzo DP
        • Braff DL
        Information processing abnormalities: Trait- and state-dependent components.
        Schizophr Bull. 1986; 12: 447-459
        • Siever LJ
        • Keefe R
        • Bernstein D
        • et al.
        Eye tracking impairment in clinically identified patients with schizotypal personality disorder.
        Am J Psychiatry. 1990; 147: 740-745
        • Siever LJ
        • Kalus OF
        • Keefe RSE
        The boundaries of schizophrenia.
        Psychiat Clin North Am. 1993; 16: 217-244
        • Spitzer RL
        • Endicott J
        • Robins E
        Research Diagnostic Criteria.
        Biometrics Research Division, London1978
        • Steronko R
        • Woods DJ
        Impairment in early stages of visual information processing in non-psychotic schizotypal individuals.
        J Abnorm Psychology. 1978; 87: 481-490