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Platelet aggregation responses to agonists have been employed as peripheral indices
of the physiological responsiveness and density of neurotransmitter receptors, and
in investigations of membrane functioning in psychopathological conditions. In particular,
there are mechanistic similarities between neuronal secretory and receptor dynamics,
and those involved in platelet dense granule secretion. Consequently, we have explored
the platelet dense granule secretory responses to various agonists in abstinent male
adolescents who meet current psychiatric diagnostic criteria for Conduct Disorder
and Psychoactive Substance Use Disorder (CD+/PSUD+) in contrast to controls (CD−/PSUD−).
The results showed a significant hyporesponsivity among experimental subjects to collagen,
thrombin, adenosine diphosphate (ADP), ADP plus 0.2 μgm of serotonin, and ADP plus 1.0 μgm of serotonin. Only dense granule responses to arachidonic acid did not differentiate
the groups. Taken together, the lack of agonist specificity suggests that a variation
in signal transduction mechanisms could account for the observed reduction in dense
granule secretion among CD+/PSUD+ adolescents. Association between dense granule secretory
responses and substance use behavior, and comorbid psychiatric conditions are also
examined.
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Article info
Publication history
Received in revised form:
August 7,
1995
Received:
April 25,
1995
Footnotes
This work was under the auspices of the Center for Education and Drug Abuse Research (a consortium of the University of Pittsburgh and St. Francis Medical Center) and supported by the National Institute on Drug Abuse (P50-DA 05605).
Identification
Copyright
© 1996 Society of Biological Psychiatry. Published by Elsevier Inc.
