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Cytokine production was previously demonstrated to be reduced in untreated major affective
patients. In addition, recovery from depression following clomipramine (CMI) treatment
was accompanied by the restoration of interleukin-1β (IL-1β) and interleukin-3-like activity (IL-3-LA) to normal range. In the present study
we assessed the in vitro production of IL-1β, IL-2, and IL-3-LA by peripheral blood mononuclear cells (PBMC) in 11 nondepressed
patients with obsessive-compulsive disorder (OCD) before and after 8 weeks of CMI
treatment. Results were compared with those of 11 healthy subjects. CMI treatment
induced a significant improvement in OCD symptoms. No alteration was observed in cytokine
production in OCD patients before treatment as compared to control subjects. Moreover,
8 weeks of drug treatment had no effect on cytokine production. In conclusion, OCD
per se, as well as CMI treatment, have no effect on interleukin production as measured
in this study.
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Article info
Publication history
Received in revised form:
August 18,
1995
Received:
March 16,
1995
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© 1996 Society of Biological Psychiatry. Published by Elsevier Inc.
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