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The binding of [3H]-nemonapride to human peripheral blood lymphocytes (PBL) was studied using various
competing ligands specific for D2-like dopamine receptors. There is no detectable
stereoselectivity for the stereoisomers of butaclamol, and competitions with haloperidol
and sulpiride also show no evidence of specific binding to D2-like dopamine receptors.
RT-PCR of RNA from human lymphocytes showed that there is no detectable D2 mRNA (even
with nested PCR). D3 mRNA was, however, detectable by RT-PCR, but only at low levels
that could not be detected by Northern blots of PBL total RNA.
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Article info
Publication history
Received in revised form:
September 15,
1995
Received:
May 30,
1995
Identification
Copyright
© 1996 Society of Biological Psychiatry. Published by Elsevier Inc.
