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A group of 20 patients who met the DSM-III-R criteria for panic disorder with or without
agoraphobia underwent a 35% carbon dioxide (CO2) challenge after either 1 mg alprazolam or placebo in a double-blind, randomized,
cross-over design. Despite the anxiolytic potential of alprazolam, it produced no
significant effects on CO2-induced anxiety and panic symptomatology when compared to placebo.
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Article info
Publication history
Received in revised form:
July 31,
1995
Received:
January 6,
1995
Identification
Copyright
© 1996 Society of Biological Psychiatry. Published by Elsevier Inc.