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Alprazolam premedication and 35% carbon dioxide vulnerability in panic patients

  • Henk Pols
    Correspondence
    Address reprint requests to Henk Pols, M.D., Department of Psychiatry & Neuropsychology, Section Clinical and Biological Psychiatry, State University of Limburg, P.O. Box 616, 6200MD, Maastricht, The Netherlands.
    Affiliations
    Department of Psychiatry & Neuropsychology, Section Clinical and Biological Psychiatry, State University of Limburg, Maastricht, The Netherlands
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  • Kees Verburg
    Affiliations
    Department of Psychiatry & Neuropsychology, Section Clinical and Biological Psychiatry, State University of Limburg, Maastricht, The Netherlands
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  • Roos Hauzer
    Affiliations
    Department of Psychiatry & Neuropsychology, Section Clinical and Biological Psychiatry, State University of Limburg, Maastricht, The Netherlands
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  • Jaap Meijer
    Affiliations
    Department of Psychiatry & Neuropsychology, Section Clinical and Biological Psychiatry, State University of Limburg, Maastricht, The Netherlands
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  • Eric Griez
    Affiliations
    Department of Psychiatry & Neuropsychology, Section Clinical and Biological Psychiatry, State University of Limburg, Maastricht, The Netherlands
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      A group of 20 patients who met the DSM-III-R criteria for panic disorder with or without agoraphobia underwent a 35% carbon dioxide (CO2) challenge after either 1 mg alprazolam or placebo in a double-blind, randomized, cross-over design. Despite the anxiolytic potential of alprazolam, it produced no significant effects on CO2-induced anxiety and panic symptomatology when compared to placebo.

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