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Monozygotic twins discordant for schizophrenia were analyzed by two-dimensional (2-D)
gel electrophoresis to identify extrahereditary factors important in the development
of schizophrenia. Plasma protein patterns in 2-D gels of monozygotic twins discordant
for schizophrenia were found to be significantly less alike than those of normal control
monozygotic twins. Several polypeptide spots were found to be elevated in the plasma
of the schizophrenic twin. One of these polypeptides, spot 782, was also found to
be significantly (p < .001) elevated when schizophrenic patients were compared to unrelated normal control
individuals. Spot 782 may be an isoform of haptoglobin. Quantitative variations in
some plasma haptoglobin levels were seen between discordant twins, but not between
unrelated schizophrenic and normal control individuals.
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Article info
Publication history
Received in revised form:
August 14,
1995
Received:
October 31,
1994
Identification
Copyright
© 1996 Society of Biological Psychiatry. Published by Elsevier Inc.
