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Twenty-nine subjects with chronic fatigue syndrome (CFS) and 25 healthy control subjects were administered a lengthy neuropsychological battery that included standard neuropsychological tests and a computerized set of tasks that spanned the same areas of ability. The primary significant differences between patients and controls were found on tests of learning and memory. These differences remained when the degree of psychiatric symptomatology in the subjects was covaried. Patients on and off psychoactive medications did not differ in their performance on these tasks. These results suggest that at least a subset of CFS patients may experience significant impairments in learning and memory.
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Received in revised form: July 28, 1995
Received: September 28, 1994
Support for this work was provided in part by grants #R01-AI27314 and #U01-AI32246 from the National Institute of Allergy and Infectious Diseases, and by a gift from the DeYoung Foundation.
© 1996 Society of Biological Psychiatry. Published by Elsevier Inc.