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The patterns of prolactin and thyrotropin (TSH) release after thyrotropin-releasing
hormone (TRH) (0.4 mg i.v.) and during the first session of a course of electroconvulsive
treatment (ECT) were studied in women with major depression, 16 in pre- and 29 in
postmenopausal status. The prolactin responses to both stimuli were lower in postmenopausal
women, whereas the TSH responses were not different. The known correlation between
the maximal prolactin response to ECT and the maximal response to TRH was significantly
stronger in the group of premenopausal women (r = .8648, versus .4249 in the postmenopausal group, p < .02). A common underlying mechanism promoting prolactin release for both stimuli
can be suggested, which diminishes after menopause, probably an influence of estradiol
on the affinity of dopaminergic and serotonergic receptors. That mechanism does not
interfere with the TSH release either by ECT or by TRH.
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Article info
Publication history
Received in revised form:
July 14,
1995
Received:
February 13,
1995
Identification
Copyright
© 1996 J. Benjamin. Published by Elsevier Inc.
