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A group of patients with major depressive disorder, with and without comorbid obsessive—compulsive
disorder, completed the Tridimensional Personality Questionnaire (TPQ). Harm Avoidance
scores were found to be high compared to published age-matched norms and to display
a significant positive correlation with Hamilton Depression Rating Scale scores. Platelet
125I-lysergic acid diethylamide (125I-LSD) and 3H-paroxetine binding Bmax values were measured to test Cloninger's hypothesis that Harm Avoidance scores would
correlate significantly with measures of serotonergic function. A significant inverse
correlation was found between Harm Avoidance scores and 125I-LSD Bmax values. Correlations between 3H-paroxetine Bmax values and TPQ scale scores were not significant. These results suggest an alternative
view of the literature relating platelet 5-hydroxytryptamine-2a receptors and mood
disorders in that the temperament dimension, Harm Avoidance, may explain prior inconsistencies
involving links with depression and suicidality.
Keywords
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Article info
Publication history
Received in revised form:
June 5,
1995
Received:
January 16,
1995
Identification
Copyright
© 1996 Society of Biological Psychiatry. Published by Elsevier Inc.
