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Depressive episodes as reversible mental states are likely to be associated with equally
reversible brain states. These can be examined with a variety of functional imaging
methods using repeated measures designs. Studies using such an approach are reviewed.
Changes in medial frontal, and in particular, cingulate cortex are reported in a majority
of studies. Similarities and differences between different study results are discussed
on the background of the functional neuroanatomy of the anterior cingulate, taking
into account a variety of neurotransmitter systems. It is concluded that neuroimaging
techniques are starting to equip us to conceptualize functional changes in the limbic
loop containing the anterior cingulate as the common denominator of change and therapy
effects in depressive states.
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Article info
Publication history
Received in revised form:
January 23,
1995
Received:
November 5,
1994
Identification
Copyright
© 1996 Society of Biological Psychiatry. Published by Elsevier Inc.
