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Mathematical models are helpful in the understanding of diseases through the use of
dynamical indicators. A previous study has shown that brain activity can be characterized
by a decrease of dynamical complexity in depressive subjects. The present paper confirms
and extends these conclusions through the use of recent methodological advances: first
episode and recurrent patients strongly differ in their dynamical response to therapeutic
interventions. These results emphasize the need for clinical follow-ups to avoid recurrence
and the necessity of specific therapeutic intervention in the case of recurrent patients.
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Article info
Publication history
Received in revised form:
April 12,
1995
Received:
November 7,
1994
Identification
Copyright
© 1996 Society of Biological Psychiatry. Published by Elsevier Inc.