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Original article| Volume 39, ISSUE 6, P430-435, March 15, 1996

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Seasonal patterns in platelet ligand binding are related to membrane proteins

  • Edward M. DeMet
    Correspondence
    Address reprint requests to Edward M. DeMet, Ph.D., Department of Psychiatry and Human Behavior, University of California, Irvine, Med. Sci. I D420, Irvine, CA 92717.
    Affiliations
    Veterans Administration Medical Center, Long Beach, CA, USA

    Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA
    Search for articles by this author
  • Aleksandra Chicz-Demet
    Affiliations
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA
    Search for articles by this author
DOI:https://doi.org/10.1016/0006-3223(95)00199-9
Seasonal patterns in platelet ligand binding are related to membrane proteins
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      A seasonal pattern of platelet [3H]imipramine (3H-IMI) binding was explained by a similar but inverted pattern in membrane protein levels in repeated measures of 20 normal volunteers. No seasonal pattern was evident when 3H-IMI binding was expressed on the basis of surface area rather than membrane protein. Platelet Bmax levels in 50 depressed patients were lower than those of controls when values were expressed in terms of platelet surface area. The results support previous reports of low Bmax values in unipolar major depression, but indicate that seasonal changes in 3H-IMI binding are due to fluctuations in membrane protein and not to changes in the number of receptive sites. The present findings also have similar implications for other platelet measures expressed in terms of membrane protein.
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      Article info

      Publication history

      Received in revised form: March 15, 1995
      Received: September 14, 1994

      Footnotes

      This research was supported by a grant from the National Institute of Mental Health (RO1 MH40468).

      Identification

      DOI: https://doi.org/10.1016/0006-3223(95)00199-9

      Copyright

      © 1996 Society of Biological Psychiatry. Published by Elsevier Inc.

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