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Effects of thyrotropin-releasing hormone administration on the electroconvulsive therapy induced prolactin responses and seizure time

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      The effects of thyrotropin-releasing hormone (TRH) administration on electroconvulsive therapy (ECT)-induced prolactin (PRL) secretion and the duration of the seizure were studied in 14 depressed women.
      In a balanced order crossover design the patients were given 0.4 mg TRH or placebo intravenously 20 min before ECT during the first two sessions. In the third ECT session TRH was given just prior to ECT. ECT elicited the expected PRL response when given alone and when given 20 min after TRH when PRL plasma levels were high. During the coadministration design (third ECT session) PRL levels were raised not as a sum of the two stimuli but even significantly more. TRH failed to modify the duration of the seizure induced by ECT. Therefore, if TRH is involved in seizure modulation during ECT, our findings suggest a postictal rather than ictal role for TRH.
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      References

        • Abrams R
        • Swartz CM
        ECT Instruction Manual for the Thymatron DG. Somatics Inc, New York1989
        • Aperia B
        • Thoren M
        • Wetterberg L
        Prolactin and thyrotropin in serum during electroconvulsive therapy in patients with major depressive illness.
        Acta Psychiatr Scand. 1985; 72: 302-308
        • Devanand DP
        • Sackeim HA
        • Pierson D
        • Novacenko H
        • Prudic J
        • Ross F
        Prolactin response to TRH and ECT; a common mechanism?.
        Biol Psychiatry. 1989; 205: 106 A
        • Dolva LO
        • Riddervold F
        • Thorsen RK
        Side effects of thyrotropin releasing hormone.
        Br Med J. 1983; 287: 532
        • Griffiths EC
        Thyrotropin releasing hormone: Endocrine and central effects.
        Psychoendocrinology. 1985; 10: 225-235
        • Ho KY
        • Smythe GA
        • Lazarus L
        The interaction of TRH and dopaminergic mechanisms in the regulation of stimulated prolactin release in man.
        Clin Endocrinol. 1985; 23: 7-16
        • Khan A
        • Mirolo MH
        • Claypoole K
        • Bhang J
        • Cox G
        • Horita A
        • Tucker G
        Effects of low-dose TRH on cognitive deficits in the ECT postictal state.
        Am J Psychiatry. 1994; 151: 1694-1696
        • Kubek MJ
        • Low WC
        • Sattin A
        • Marzorati SL
        • Meyerhoff JL
        • Larsen SH
        Role of TRH in seizure modulation.
        Ann NY Acad Sci. 1989; 553: 286-303
        • Lankford HV
        • Blackard WG
        • Gardner DF
        • Tucker HSTG
        Effects of thyrotropin-releasing hormone and metoclopramide in patients with phenothiazine-induced hyperprolactinemia.
        J Clin Endocrinol Metab. 1981; 53: 109-112
        • Maeda K
        • Tanimoto K
        Epileptic seizures induced by thyrotropin releasing hormone.
        Lancet. 1981; 1: 1058-1059
        • Metcalf G
        Regulatory peptides as a source of new drugs—the clinical prospects for analogues of TRH which are resistant to metabolic degradation.
        Brain Res Rev. 1982; 4: 389-408
        • Ohman R
        • Balldin J
        • Walinder J
        • Wallin L
        Prolactin response to electroconvulsive therapy.
        Lancet. 1976; 1: 936-938
        • Papakostas Y
        • Markianos M
        • Papadimitriou G
        • Lykouras L
        • Stefanis C
        Thyrotropin and prolactin responses to ECT in schizophrenia and depression.
        Psychiatry Res. 1991; 37: 5-10
        • Papakostas Y
        • Markianos M
        • Papadimitriou G
        • Stefanis C
        Prolactin response induced by ECT and TRH.
        Br J Psychiatry. 1986; 148: 721-723
        • Post RM
        • Weiss SRB
        Endogenous biochemical abnormalities in affective illness: Therapeutic versus pathogenic.
        Biol Psychiatry. 1992; 32: 469-484
        • Rojdmark S
        • Rossner S
        Decreased dopaminergic control of prolactin secretion in male obesity: Normalisation by fasting.
        Metabolism. 1991; 40: 191-195
        • Swartz CM
        Clinical and Laboratory Predictors of ECT Response.
        in: Coffey CE The Clinical Science of Electroconvulsive Therapy. American Psychiatric Press, Chicago IL1993
        • Ylikorkala O
        • Kivinen S
        • Vinikka L
        Regulation of prolactin and thyrotropin secretion during human pregnancy: Effect of sulpiride and TRH administration.
        Acta Endocrinol. 1981; 98: 451-455
        • Zis AP
        • McGarvey KA
        • Clark CM
        • Lam RW
        • Adams SA
        The role of dopamine in seizure-induced prolactin release in humans.
        Convuls Ther. 1992; 8: 126-130