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The effects of thyrotropin-releasing hormone (TRH) administration on electroconvulsive
therapy (ECT)-induced prolactin (PRL) secretion and the duration of the seizure were
studied in 14 depressed women.
In a balanced order crossover design the patients were given 0.4 mg TRH or placebo
intravenously 20 min before ECT during the first two sessions. In the third ECT session
TRH was given just prior to ECT. ECT elicited the expected PRL response when given
alone and when given 20 min after TRH when PRL plasma levels were high. During the
coadministration design (third ECT session) PRL levels were raised not as a sum of
the two stimuli but even significantly more. TRH failed to modify the duration of
the seizure induced by ECT. Therefore, if TRH is involved in seizure modulation during
ECT, our findings suggest a postictal rather than ictal role for TRH.
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Article info
Publication history
Received in revised form:
March 8,
1995
Received:
September 7,
1994
Identification
Copyright
© 1996 Society of Biological Psychiatry. Published by Elsevier Inc.
