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This study examined whether there is evidence for an association between alcoholism
and the alleles of the TaqI A, TaqI B, and short tandem repeat polymorphisms (STRP),
both individually and as haplotypes, at the dopamine D2 receptor gene (DRD2) in males
of three populations from Taiwan. We studied 46 Chinese Han (21 alcoholics and 25
nonalcoholics), 42 Atayal (21 alcoholics and 21 nonalcoholics), and 40 Ami (20 alcoholics
and 20 nonalcoholics). Alcoholism was diagnosed according to DSM-III-R criteria and
all individuals in the alcoholic groups were severely affected. Significant linkage
disequilibrium occurs for the three polymorphic sites in all three populations. No
significant association was observed between any of the three polymorphisms at the
DRD2 locus, tested individually and as haplotypes, and alcoholism in the three subject
groups. We conclude that no association exists between genetic variation at the DRD2
locus and alcoholism in Chinese Han, Atayal, and Ami males.
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Publication history
Received in revised form:
March 6,
1995
Received:
July 22,
1994
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© 1996 Society of Biological Psychiatry. Published by Elsevier Inc.
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