Gender differences in corpus callosum size in first-episode schizophrenics

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      Previous studies indicate differences between schizophrenics and normals in thickness and overall size of the corpus callosum, particularly in female subjects. The present study compares the area of the corpus callosum as measured by magnetic resonance imaging (MRI) in men and women experiencing first-episode cases of schizophrenia. The corpus callosum area is also correlated with measures of neuropsychological function. The results of this study suggest that women who are first-episode schizophrenic patients have a smaller total corpus callosum area than female controls, with no difference noted for men. In normal controls, a larger corpus callosum was associated with better cognitive function, whereas in schizophrenics, no such relationship emerged.


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        • Bigelow L.
        • Nasrallah H.
        • Rauscher F.
        Corpus callosum thickness in chronic schizophrenia.
        Br J Psychiatry. 1983; 142: 284-287
        • Coger R.W.
        • Serafetinides E.A.
        Schizophrenia, corpus callosum, and interhemispheric communication: A review.
        Psychiatry Res. 1990; 34: 163-184
        • De LaCoste-Utamsing M.
        • Holloway R.
        Sexual dimorphism in the humam corpus callosum.
        Science. 1982; 216: 1431-1432
        • DeLisi L.
        • Dauphinais D.
        • Hauser P.
        Gender differences in the brain: Are they relevant to the pathogenesis of schizophrenia.
        Compr Psychiatry. 1989; 30: 197-208
        • Flaum M.
        • Arndt S.
        • Andreasen N.C.
        Role of gender in studies of ventricle enlargement in schizophrenia: A predominantly male effect.
        Am J Psychiatry. 1990; 147: 1327-1332
        • Forrest A.
        • Hay A.
        Sex differences and the schizophrenic experience.
        Acta Psychiatr Scand. 1971; 47: 137-149
        • Gazzaniga M.
        The Bisected Brain.
        Appleton-Century-Crofts, New York1970
        • Goldstein J.
        • Santangelo S.
        • Simpson J.
        • Tsuang M.
        The role of gender in identifying subtypes of schizophrenia: A latent class analytic approach.
        Schizophr Bull. 1990; 16: 263-275
        • Haas G.L.
        • Sweeney J.A.
        • Hein D.A.
        • Goldman D.
        • Deck M.
        Sex differences in the course of schizophrenia.
        Clin Neuropsychologist. 1991; 5: 281-282
        • Hauser P.
        • Dauphinais D.
        • Berrettini W.
        • DeLisi L.E.
        • Gelernter J.
        • Post R.M.
        Corpus callosum dimensions measured by magnetic resonance imaging in bipolar affective disorder and schizophrenia.
        Biological Psychiatry. 1989; 26: 659-668
        • Hoff A.L.
        • Riordan H.
        • DeLisi L.E.
        Influence of gender on neuropsychological testing and MRI measures of schizophrenic inpatients.
        Clin Neuropsychol. 1991; 5: 281
        • Hoff A.L.
        • Riordan H.
        • O'Donnell D.
        • et al.
        Anomalous lateral sulcus asymmetry and cognitive function in first-episode schizophrenia.
        Schizophr Bull. 1992; 18: 257-272
        • Hoff A.
        • Riordan H.
        • O'Donnell D.
        • Morris L.
        • DeLisi L.E.
        Neuropsychological functioning of first-episode schizophreni-form patients.
        Am J Psychiatry. 1992; 149: 898-903
        • Holloway R.
        • de LaCoste-Utamsing M.
        Sexual dimorphism in the human corpus callosum: An extension and relication study.
        Human Neurobiol. 1986; 5: 87-91
        • Kertesz A.
        • Polk M.
        • Howell T.
        • Black S.E.
        Cerebral dominance, sex and callosal size in MRI.
        Neurology. 1987; 37: 1385-1388
        • Lewine R.R.
        • Flashman L.
        • Gulley L.
        • et al.
        Sexual dimorphism in corpus callosum and schizophrenia.
        Schizophr Res. 1991; 4: 63-64
        • Lewine R.R.
        • Gulleu L.R.
        • Risch S.C.
        • Jewart R.
        • Houpt J.L.
        Sexual dimorphism, brain morphology, and schizophrenia.
        Schizophr Bull. 1990; 16: 195-203
        • Loranger A.
        Sex differences in age of onset of schizophrenia.
        Arch Gen Psychiatry. 1984; 41: 157-161
        • McGlashan T.
        • Bardenstein K.
        Gender differences in affective, schizoaffective, adn schizophrenic disorders.
        Schizophr Bull. 1990; 16: 319-329
        • Myers J.K.
        • Bean L.L.
        A Decade Later: A Follow-up of Social Class and Mental Illness.
        Wiley, New York1968
        • Nasrallah H.
        • Andreasen N.
        • Coffman J.
        • et al.
        A controlled magnetic resonance imaging study of corpus callosum thickness in schizophrenia.
        Biol Psychiatry. 1986; 21: 272-282
        • Perlick D.
        • Mattis S.
        • Statsny P.
        • Teresi T.
        Neuropsychological discriminators of long-term inpatient or outpatient status in chronic schizophrenia.
        Neuropsychiat Clin Neurosci. 1992; 4: 428-434
        • Perlick D.
        • Stastny P.
        • Mattis S.
        • Teresi J.
        Contributions of family, cognitive and clinical dimensions to long-term outcome in schizophrenia.
        Schizophr Res. 1992; 6: 257-265
        • Perlick D.
        • Mattis S.
        • Stastny P.
        • Teresi J.
        Gender differences in cognition in schizophrenia.
        Schizophr Res. 1992; 8: 69-73
        • Pfohl B.
        • Blum N.
        • Zimmerman M.
        • Stangl D.
        Structured Interview for DSM-III-R Personality Disorders—Revised (SIDP-R).
        The University of Iowa, Iowa City, IA1990
        • Raine A.
        • Andrews H.
        • Sheard C.
        • Walder C.
        • Manders D.
        Interhemispheric transfer in schizophrenics, depressives, and normals with schizoid tendencies.
        J Abnorm Psychol. 1989; 98: 35-41
        • Raine A.
        • Harrison G.N.
        • Reynolds G.P.
        • Sheard C.
        • Cooper J.E.
        • Medlye I.
        Structural and functional characteristics of the corpus callosum in schizophrenics, psychiatric controls, and normal controls.
        Arch Gen Psychiatry. 1990; 47: 1060-1065
        • Rosenthal R.
        • Bigelow L.
        Quantitative brain measurements in chronic schizophrenia.
        Br J Psychiatry. 1972; 121: 259
        • Rossi A.
        • Stratta P.
        • Gallucci M.
        • Passariello R.
        • Casacchia M.
        Quantification of corpus callosum and ventricles in schizophrenia with nuclear magnetic resonance imaging: A pilot study.
        Am J Psychiatry. 1989; 146: 99-101
        • Spitzer R.L.
        • Endicott J.
        The Schedule for Affective Disorders and Schizophrenia-Lifetime Version (SADS-L).
        New York State Psychiatric Institute, Biometrics Research Division, New York1978
        • Uematsu M.
        • Kaiya H.
        The morphology of the corpus callosum in schizophrenia: An MRI study.
        Schizophr Res. 1988; 1: 391-398