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A heightened response to the muscarinic effects of acetylcholine appears to be involved
in many of the symptoms associated with affective disorders. We have developed an
animal model for cholinergic supersensitivity to study this involvement in more detail.
Our findings on cholinergic supersensitivity and on behavioral despair in this model,
the WAGxDA F1 hybrid, are reported here. Female WAGxDA rats show a heightened response
to muscarinic agonist in a temperature depression test (TDT) and both males and females
show an increased level of inherent despair in a Porsolt swim test; however, this
cholinergic supersensitivity does not appear to be based on an increased density or
affinity of cholinergic receptors. Other possible mechanisms are discussed.
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Article info
Publication history
Received in revised form:
August 10,
1994
Received:
July 16,
1993
Identification
Copyright
© 1995 Society of Biological Psychiatry. Published by Elsevier Inc.
