This paper is only available as a PDF. To read, Please Download here.
Dysthymic depressed patients showed platelet-serotonin (pS) + plasma-free serotonin
values greater than normal as well as plasma noradrenaline values lower than normal
during supine resting period (0′). Conversely, no significant differences were observed
in the 0′ values of any other of the measured parameters: systolic, diastolic and
differential blood pressure (SBP, DBP, DP), heart rate (HR), adrenaline (Ad), dopamine
(DA), cortisol, and platelet aggregability between patients and controls. Although
patients showed the normal DP reduction at orthosthasis (1′), this was not prevented
by atropine as it does in controls. Patients but not normals showed significant rises
of DBP at orthostasis and exercise (5′) periods, which were positively correlated
with NA rises. On the contrary, the abnormally raised resting fS values registered
in patients showed progressive and significant reductions throughout the test that
were negatively correlated with DBP-NA values. Adrenaline did not show the normal
5′-fS peak. The above findings suggest that dysthymics show hypoactivity of the two
branches of the sympathetic system (neural + adrenal) along with hyperparasympathetic
activity. Furthermore, their low NA + high pS values contrast with the high NA + low
pS registered in major depressed subjects.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Biological PsychiatryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- 3rd ed rev. Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Press, New York1987
- Neurochemical changes elicited by stress.in: Anisman H Bignami G Psychopharmacology of aversively motivated behavior. Plenum Press, Washington DC1978: 119-172
- Effect on human platelets of catecholamines at levels achieved in the circulation.Atherosclerosis. 1985; 58: 251-259
- An inventory for measuring depression.Arch Gen Psychiatry. 1961; 4: 561-571
- Aggregation of blood platelets by adenosine diphosphate and its reversal.Nature. 1962; 194: 927-929
- Interrelationships of platelet-aggregation and secretion.J Clin Invest. 1977; 60: 866-874
- Routine determination of plasma catecholamines using reversed phase ion-pair high-performance liquid chromatography with electrochemical detection.J Chromatogr. 1982; 231: 41-51
- Content and subcellular localization of catecholamines and 5-hydroxytryptamine in human and animal blood platelets, monoamine distribution between platelets and plasma.Br J Pharmacol. 1979; 65: 653-662
- Selective noradrenaline depletion markedly alters stress responses in rats.Life Sci. 1985; 37: 461-465
- Vagal release of serotonin into gut lumen and portal circulation via separate control mechanisms.J Surg Res. 1987; 43: 205-210
- Effect of emotional stress on platelet aggregation in humans.Chest. 1976; 70: 501-505
- The effects of alpha adrenergic agents on human blood platelet aggregation.J Pharmacol Exp Ther. 1979; 208: 366-372
- Adrenaline-induced platelet aggregation in depressed patients and control subjects.Biol Psychiatry. 1993; 27: 21-25
- Platelet adrenoceptors.in: Longenecker GL The Platelets: Physiology and Pharmacology. Academic Press Inc Ltd., New York1985: 113-157
- Catecholamines in individual hypothalamic nuclei in stressed rats.in: Usdin E Kvetnansky R Kopin I Catecholamines and Stress. Pergamon Press, London1976: 39-50
- Effects of chronic guanethidine treatment and adrenal medullectomy on plasma levels of catecholamines and corticosterone in forcibly immobilized rats.J Pharmacol Exp Ther. 1979; 209: 287-291
- Effects of adrenaline infusion on platelet number, volume and release reaction.Thromb Haemost. 1985; 54: 450-453
- Altered platelet function during mental stress and adrenaline infusion in humans: evidence for an increased aggregabiity in vivo as measured by filtragometry.Clin Sci. 1989; 76: 369-376
- Plasma neurotransmitters, blood pressure and heart rate during rest and exercise.Am J Respir Crit Care Med. 1994; 149 (Abstract) (American Thoracic Society International Conference. Boston, Mass, May 21–25): A482
- Plasma catecholamines and indoleamines during attacks and remission on severe bronchial asthma: possible role of stress.Am J Respir Crit Care Med. 1994; 149 (American Thoracic Society International Conference, Boston, Mass. May 21–25): A778
- Plasma neurotransmitters, blood pressure, and heart rate during supine-resting, orthostasis, and moderate exercise in dysthymic depressed patients.Biol Psychiatry. 1995; 37: 884-891
- Plasma neurotransmitters throughout oral glucose tolerance test in non-depressed essential hypertension patients.Clin Exp Hypertens. 1993; 15: 209-240
- Effects of an oral glucose load on plasma neurotransmitters in humans: involvement of REM sleep?.Neuropsychobiology. 1992; 26: 4-11
- Dramatic improvement with clonidine in acute pancreatitis with elevated catecholamine and cortisol plasma levels: report of five cases.J Med. 1992; 23: 339-351
- Doxepin therapy for postprandial symptomatic hypoglycaemic patients: neurochemical, hormonal and metabolic disturbances.Clin Sci. 1991; 80: 373-384
- Plasma neurotransmitters and cortisol in duodenal ulcer patients.Dig Dis Sci. 1990; 35: 1313-1319
- Psychoneuroendocrinological and immunological parameters in cancer patients: involvement of stress and depression.Psychoneuroendocrinology. 1990; 15: 435-451
- Pimozide therapy for trigeminal neuralgia.Arch Neurol. 1989; 46: 960-963
- Plasma neurotransmitters profile in depressive syndromes.Arch Ven Farmacol Terap. 1988; 7 (Abstract) (III Interamerican Congress of Clinical Pharmacology and Therapeutics and XII Latinamerican Congress of Pharmacology. Caracas, Venezuela, October 2–7): A7
- Plasma neurotransmitters profile in chronic illness.Arch Ven Farmacol Terap. 1988; 7 (Abstract) (III Interamerican Congress of Clinical Pharmacology and Therapeutics and XII Latinamerican Congress of Pharmacology, Caracas, Venezuela, October 2–7): A38
- Role of stress in the exacerbation of chronic illness: effects of clonidine administration on blood pressure and plasma norepinephrine, cortisol, growth hormone and prolactin concentrations.Psychoneuroendocrinology. 1987; 12: 117-129
- Effects of Clonidine on blood pressure, noradrenaline, cortisol, growth hormone, and prolactin plasma levels in high and low intestinal tone subjects.Neuroendocrinology. 1985; 40: 253-261
- Effects of clonidine on blood pressure, noradrenaline, cortisol, growth hormone, and prolactin plasma levels in high and low intestinal tone depressed patients.Neuroendocrinology. 1985; 41: 156-162
- Distal colon motility and clinical parameters in depression.J Affect Dis. 1983; 5: 19-26
- Platelet activation and secretion associated with emotional stress.Circulation. 1985; 71: 1129-1134
- Serotonin uptake in blood platelets in psychiatric patients.Arch Gen Psychiatry. 1987; 30: 1322-1326
- Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radio-assay.J Clin Endocrinol Metab. 1967; 27: 973-990
- Platelet function in surgical stress.Thromb Haemost. 1985; 54: 849-852
- Platelet aggregation in whole blood: is the response to adrenaline, 5-hydroxytryptamine and PAF a direct consequence of stimulation by these agonists?.Thromb Res. 1989; 54: 151-159
- Determination of serotonin in plasma by liquid chromatography with electrochemical detection.J Chromatogr. 1985; 341: 445-451
- Physostigmine effects on serotonin uptake in human blood platelets.Eur J Pharmacol. 1985; 109: 91-96
- Comparative assessment of stimuli that release neuronal and adrenomedullary catecholamines in man.Circulation. 1979; 59: 637-643
- Epinephrine, norepinephrine, dopamine and serotonin: differential effects of acute and chronic stress on regional brain amines.Brain Res. 1982; 239: 417-424
- Circadian variation of serotonin levels in human blood.Horm Metab Res. 1976; 8: 157-158
- Cholinergic modulation of the release of 5-hydroxytryptamine from the guinea pig ileum.Naunyn Schmiedeberg's Arch Pharmacol. 1987; 336: 127-132
- Release mechanisms of 5-HT in mammalian gastrointestinal tract—especially vagal release of 5-HT.in: Fujita T Endocrine Gut and Pancreas. Elsevier Publishing Co, Oxford, UK1976: 371-380
- Relationship of catecholamines, histamine and serotonin in men under different kinds of stress.in: Usdin E Kvetnansky R Kopin I Catecholamines and Stress. Pergamon Press, Amsterdam1976: 527-528
- Diurnal and seasonal variations in human platelet serotonin in man.J Neural Transm. 1977; 41: 7-15
- Dissociation of sympathetic nervous system and adrenal medullary responses.Am J Physiol. 1984; 247 (Endocrinol Metab): E35-E40
Article info
Publication history
Received in revised form:
July 27,
1994
Received:
January 28,
1994
Identification
Copyright
© 1995 Society of Biological Psychiatry. Published by Elsevier Inc.
