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Cerebral glucose metabolism was studied in 20 underweight anorectic girls and in 10
age- and sex-matched healthy volunteers using positron emission tomography with (18-F)-fluorodeoxy-glucose.
Both groups were scanned during rest, with eye closed and with low ambient noise.
Compared to controls, the underweight anorectic group showed a global hypometabolism
(p = .002) and an absolute (p < .001) as well as relative (p < .01) hypometabolism of glucose in cortical regions, with the most significant differences
found in the frontal and the parietal cortices. Within the underweight anorectic and
the control groups, no correlations were found between absolute or relative rCMRGlu
and BMI, anxiety scores, or Hamilton scores of depression. Different factors might
explain this reduction of glucose metabolism in anorexia nervosa. It might be the
consequence of neurophysiological or morphological aspects of anorexia nervosa and/or
the result of some associated symptoms such as anxiety or depressed feelings. Supported
by cognitive studies, we can also hypothesize a primary corticocerebral dysfunctioning
in anorexia nervosa.
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Article info
Publication history
Received in revised form:
March 21,
1994
Received:
November 30,
1993
Identification
Copyright
© 1995 Society of Biological Psychiatry. Published by Elsevier Inc.
